An alternate synthesis of sporiolide B from (R)-glyceraldehyde

In this article, a novel synthetic route was described for the total synthesis of Sporiolide B from inexpensive and commercially available starting materials by a concise fourteen-step sequence in 6.50% overall yield. This convergent synthesis utilizes Grignard reaction, Asymmetric dihydroxylation,...

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Bibliographic Details
Published in:Synthetic communications 2023-08, Vol.53 (16), p.1333-1338
Main Authors: Kokkiligadda, Suresh Babu, Musunuri, Sivanadh, Syed, Tasqeeruddin, Maiti, Bhimcharan, Mandava Venkata, Basaveswara Rao
Format: Article
Language:English
Subjects:
12-membered lactones
Chemical synthesis
Grignard reaction
Grignard reactions
Metathesis
sporiolide B
Yamaguchi macrolactonization and ring closing metathesis
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Summary:In this article, a novel synthetic route was described for the total synthesis of Sporiolide B from inexpensive and commercially available starting materials by a concise fourteen-step sequence in 6.50% overall yield. This convergent synthesis utilizes Grignard reaction, Asymmetric dihydroxylation, Yamaguchi macrolactonization and ring closing metathesis as the key steps.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2023.2220443