Iodohydrins: An Easy Route to Epoxides from Alkenes

The preparation of epoxides is efficiently achieved by reaction of alkenes with I 2 in aqueous dioxane in the presence of Cu(OAc) 2 .H 2 O followed by treatment with KOH in a biphasic system (H 2 O/ether/pentane).

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Bibliographic Details
Published in:Synthetic communications 1998-02, Vol.28 (3), p.559-572
Main Authors: Sanseverino, Antonio Manzolillo, de Mattos, Marcio C. S.
Format: Article
Language:English
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Summary:The preparation of epoxides is efficiently achieved by reaction of alkenes with I 2 in aqueous dioxane in the presence of Cu(OAc) 2 .H 2 O followed by treatment with KOH in a biphasic system (H 2 O/ether/pentane).
ISSN:0039-7911
1532-2432
DOI:10.1080/00397919808005111