Colloidal assemblies: effective extraction media for diazepam from impaled blood, urine and milk samples

Extraction of diazepam (DZP) from complex matrices, i.e. blood, milk and urine, has been carried out using conventional solvents and surfactant formulations. The formulations have been spectrophotometrically (A) analysed and method specificity has been depicted through first-order derivative (D1) sp...

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Published in:Australian journal of forensic sciences 2019-03, Vol.51 (2), p.171-181
Main Authors: Kori, Shivpoojan, Parmar, Ankush, Sharma, Shweta
Format: Article
Language:English
Subjects:
Analysis
Blood
Body fluids
Comparative studies
CRIMINAL INVESTIGATION
Diazepam
DRUG ABUSE
Drug traffic
Drugs
DRUGS AND CRIME
extraction
Forensic medicine
FORENSIC SCIENCE
Forensic sciences
forensics
Investigation
Sedatives
SEXUAL OFFENCES
Solvents
Spectrophotometry
Surface active agents
surfactant
Surfactants
Toxicity testing
Toxicology
Urine
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cited_by cdi_FETCH-LOGICAL-c472t-bf7818ebcd679f23644abb3ebfb1125b3e6b94d4ad63c7531d114d8785773d9c3
cites cdi_FETCH-LOGICAL-c472t-bf7818ebcd679f23644abb3ebfb1125b3e6b94d4ad63c7531d114d8785773d9c3
container_end_page 181
container_issue 2
container_start_page 171
container_title Australian journal of forensic sciences
container_volume 51
creator Kori, Shivpoojan
Parmar, Ankush
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description Extraction of diazepam (DZP) from complex matrices, i.e. blood, milk and urine, has been carried out using conventional solvents and surfactant formulations. The formulations have been spectrophotometrically (A) analysed and method specificity has been depicted through first-order derivative (D1) spectrophotometry. A comparative study between conventional solvents and surfactant formulations has been performed for the recovery (%R) of the drug. Among all the employed formulations, non-ionic surfactant, Brij-58 (3 mM)/EtOH (1:1) possessed maximum extraction efficiency. The significance of the study can be envisaged as surfactant-based formulations acting as a potent vector for extraction of diazepam, which can be scaled up for varied applications.
doi_str_mv 10.1080/00450618.2017.1334825
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source Taylor and Francis Science and Technology Collection
subjects Analysis
Blood
Body fluids
Comparative studies
CRIMINAL INVESTIGATION
Diazepam
DRUG ABUSE
Drug traffic
Drugs
DRUGS AND CRIME
extraction
Forensic medicine
FORENSIC SCIENCE
Forensic sciences
forensics
Investigation
Sedatives
SEXUAL OFFENCES
Solvents
Spectrophotometry
Surface active agents
surfactant
Surfactants
Toxicity testing
Toxicology
Urine
title Colloidal assemblies: effective extraction media for diazepam from impaled blood, urine and milk samples
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