Novel Thermoreversible Injectable Hydrogel Formulations Based on Sodium Alginate and Poly(N-Isopropylacrylamide)

Novel injectable thermoreversible hydrogel compositions with semi-interpenetrating network structure were prepared through the addition of sodium alginate (SA) to poly(N-isopropylacrylamide) (PNIPAM) aqueous solutions. The addition of the hydrophilic alginate strongly improved the stability against...

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Bibliographic Details
Published in:International journal of polymeric materials 2015-11, Vol.64 (15), p.763-771
Main Authors: Teodorescu, Mircea, Andrei, Maria, Turturicǎ, Gabriel, Stǎnescu, Paul O., Zaharia, Anamaria, Sârbu, Andrei
Format: Article
Language:English
Subjects:
Aqueous solutions
Biomedical materials
Hydrogels
Injectable hydrogels
Molecular weight
poly(N-isopropylacrylamide)
sodium alginate
thermogelation
thermoresponsive
Viscoelasticity
Viscosity
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Summary:Novel injectable thermoreversible hydrogel compositions with semi-interpenetrating network structure were prepared through the addition of sodium alginate (SA) to poly(N-isopropylacrylamide) (PNIPAM) aqueous solutions. The addition of the hydrophilic alginate strongly improved the stability against syneresis of the 15 wt% PNIPAM hydrogels formed at 37°C from less than 15 min in the absence of alginate to more than 7 days in the presence of 4 wt% SA. Besides the SA concentration, the hydrogel stability depended on the molecular weight and polydispersity of PNIPAM, being lower when a high molecular weight fraction was present. The phase transition temperature (T ph ) of the PNIPAM aqueous solutions decreased with alginate concentration, while the dynamic viscosity and elastic modulus of the hydrogels increased. By decreasing the PNIPAM molecular weight and polydispersity, the dynamic viscosity and elastic modulus of the PNIPAM-alginate hydrogels formed above T ph diminished, while their viscoelastic behavior changed from predominantly elastic to predominantly viscous.
ISSN:0091-4037
1563-535X
DOI:10.1080/00914037.2015.1030646