Stabilized polymeric nanoparticle from amphiphilic mPEG-b-polyaspartamides containing 'click' functional groups

The synthesis of a series of poly(ethylene glycol) and polyaspartamide-based block copolymers containing azide and alkyne function groups and its micelle formation in aqueous solution were described. The self-assembly behavior of these amphiphilic copolymers in aqueous media to form nanosized micell...

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Bibliographic Details
Published in:International journal of polymeric materials 2017-10, Vol.66 (15), p.798-804
Main Authors: Bui, Quang Tri, Jeon, Young Sil, Kim, Jaeyun, Kim, Ji-Heung
Format: Article
Language:English
Subjects:
Alkynes
Amphiphilic copolymer
Block copolymers
Chemical reactions
Chemical synthesis
click reaction
Copolymers
core-crosslinking
Crosslinking
Current carriers
Dilution
Drug delivery systems
Functional groups
MPEG encoders
Nanoparticles
Particle size
Photon correlation spectroscopy
Polyethylene glycol
polymeric micelle
Self-assembly
Video compression
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Description
Summary:The synthesis of a series of poly(ethylene glycol) and polyaspartamide-based block copolymers containing azide and alkyne function groups and its micelle formation in aqueous solution were described. The self-assembly behavior of these amphiphilic copolymers in aqueous media to form nanosized micelle and the core-crosslinking reaction to convert them to stable nanoparticle were investigated. The particle size distributions were measured by dynamic light scattering. The resulting nanogel, prepared by click reaction within the mixed micelle core, has been shown to exhibit stability upon dilution and also in the presence of SDS, a small-molecule surfactant, suggesting the potential use as carrier for current drug delivery system.
ISSN:0091-4037
1563-535X
DOI:10.1080/00914037.2016.1263957