Group IVB metallocene polyesters containing camphoric acid and preliminary cancer cell activity

Polyesters were formed from the reaction of the salt of camphoric acid and Group IVB metallocene dichlorides using the interfacial polycondenzation process. The polyesters were formed in good yields with moderate chain lengths. Fourier transform infrared spectroscopy shows bands characteristic of th...

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Bibliographic Details
Published in:International journal of polymeric materials 2018-05, Vol.67 (8), p.469-479
Main Authors: Carraher, Charles E., Roner, Michael R., Campbell, Anthony G., Moric-Johnson, Alisa, Miller, Lindsey, Slawek, Paul, Mosca, Francesca
Format: Article
Language:English
Subjects:
Biotechnology
Breast cancer
camphoric acid
Cancer
Carbonyl groups
Carbonyls
Desorption
Dichlorides
Fourier transforms
Group IVB polymers
Ionization
Ions
Lasers
metallocene-containing polymers
NMR
Nuclear magnetic resonance
pancreatic cancer
Polyester resins
Polymers
Spectrum analysis
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Summary:Polyesters were formed from the reaction of the salt of camphoric acid and Group IVB metallocene dichlorides using the interfacial polycondenzation process. The polyesters were formed in good yields with moderate chain lengths. Fourier transform infrared spectroscopy shows bands characteristic of the presence of both reactants with new bands characteristic of the formation of the M‒O and M-O(CO) linkage present. The polymers largely exist in a bridging geometry of the carbonyl groups about the metal atom. Nuclear magnetic resonance shows the presence of bands derived from both reactants. Matrix-assisted laser desorption/ionization mass spectroscopy shows ion fragments to three units for the polymers with isotopic abundance characteristic of the presence of metal atoms in the ion fragment clusters. All the polymers exhibit good ability to inhibit all the tested cancer cell lines but the zironocene and hafnocene polymers exhibit especially good inhibition of the tested cancer cell lines that included two pancreatic cancer cell lines. They represent a potential new group of anticancer drugs.
ISSN:0091-4037
1563-535X
DOI:10.1080/00914037.2017.1342254