Modulation of vascular endothelial cells under shear stress on electrospun membranes containing REDV and microRNA-126

For blood vessel regeneration, rapid endothelialization is essential by the effective modulation of vascular endothelial cells (VECs). Herein, microRNA-126 was loaded in electrospun membranes of poly(ethylene glycol)-b-poly(L-lactide-co-ε-caprolactone) combined with REDV peptide to promote VEC growt...

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Bibliographic Details
Published in:International journal of polymeric materials 2021-10, Vol.70 (15), p.1090-1099
Main Authors: Wen, Meiling, Yan, Hongyu, Shi, Xin, Zhao, Yunhui, Wang, Kai, Kong, Deling, Yuan, Xiaoyan
Format: Article
Language:English
Subjects:
Blood vessels
Electrospinning
Electrospun membranes
Endothelial cells
Mechanical properties
Membranes
microRNA-126
MicroRNAs
Modulation
Morphology
Polyethylene glycol
REDV peptide
Regeneration
Ribonucleic acid
RNA
Shear stress
vascular endothelial cells
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Summary:For blood vessel regeneration, rapid endothelialization is essential by the effective modulation of vascular endothelial cells (VECs). Herein, microRNA-126 was loaded in electrospun membranes of poly(ethylene glycol)-b-poly(L-lactide-co-ε-caprolactone) combined with REDV peptide to promote VEC growth. The prepared electrospun membranes with suitable mechanical properties in the wet state could accelerate microRNA-126 release to 82.5 ± 4.0% in 56 days. VECs cultured on the electrospun membranes exhibited enhanced adhesion and proliferation with elongating and aligning morphology to the flow direction under shear stress compared with the static culture. The electrospun membranes containing REDV and microRNA-126 could have great potential in applications of bioactive vascular grafts.
ISSN:0091-4037
1563-535X
DOI:10.1080/00914037.2020.1785452