Redox-responsive dasatinib-containing hyaluronic acid prodrug and co-delivery of doxorubicin for cancer therapy

Redox-responsive prodrugs were synthesized by conjugating dasatinib (Das)/cholesterol (Chol) to hyaluronic acid (HA) via the cystamine dihydrochloride (Cys), and hexamethylene diamine (Hda) linkers. In a redox environment (10 mM dithiothreitol, DTT), a substantial amount of the grafted Das was relea...

Full description

Saved in:
Bibliographic Details
Published in:International journal of polymeric materials 2021-12, Vol.70 (18), p.1329-1343
Main Authors: Lin, Yin-Ku, Wang, Shiu-Wei, Lee, Ren-Shen
Format: Article
Language:English
Subjects:
Cholesterol
dasatinib
Diamines
Doxorubicin
Flow cytometry
Hyaluronic acid
Micelles
Prodrug
redox-responsive
Toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Redox-responsive prodrugs were synthesized by conjugating dasatinib (Das)/cholesterol (Chol) to hyaluronic acid (HA) via the cystamine dihydrochloride (Cys), and hexamethylene diamine (Hda) linkers. In a redox environment (10 mM dithiothreitol, DTT), a substantial amount of the grafted Das was released and faster than that observed under physiological conditions. The cytotoxicity of redox-sensitive HA-Cys-P(SSDas/CCChol) was greater than that of redox-insensitive HA-Hda-PCCDas. Flow cytometry showed that the uptake of HA-targeted DOX-encapsulated micelles was faster than that of free DOX.
ISSN:0091-4037
1563-535X
DOI:10.1080/00914037.2020.1798434