Smart nanocarrier-based chitosan @silica coated carbon nanotubes composite for breast cancer treatment approach

The nonspecificity of doxorubicin (DOX), as well as its oral bioavailability, is a major obstacle in the clinical setting. This study was based on the change of pH value and designed for the 1st time a novel nano-matrix; multiwall carbon nanotubes (MWCNTs) coated with mesoporous silica (MS) and chit...

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Bibliographic Details
Published in:International journal of polymeric materials 2022-08, Vol.71 (12), p.910-922
Main Authors: El-Shahawy, Ahmed A. G., Elnagar, Noha, Zohery, Medhat, Abd Elhafeez, Maha Sabry, El-Dek, S. I.
Format: Article
Language:English
Subjects:
Bioavailability
Carbon nanotubes
Chitosan
Doxorubicin
drug delivery
Entrapment
Multi wall carbon nanotubes
silica
Silicon dioxide
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Summary:The nonspecificity of doxorubicin (DOX), as well as its oral bioavailability, is a major obstacle in the clinical setting. This study was based on the change of pH value and designed for the 1st time a novel nano-matrix; multiwall carbon nanotubes (MWCNTs) coated with mesoporous silica (MS) and chitosan (CS). The latter possessed a unique nanostructure with pH-sensitivity in DOX release to be administered orally for the treatment of breast cancer. The loaded DOX and entrapment efficiency reached 64% and 99%, respectively. The results of MWCNTs@MS@CS@DOX confirmed its efficiency as pH-based drug delivery for oral breast cancer therapy.
ISSN:0091-4037
1563-535X
DOI:10.1080/00914037.2021.1925277