Synthesis, characterization and initial biological studies of a new platinum(II) complex with deoxyalliin

A new platinum(II) complex with deoxyalliin was synthesized and characterized by chemical and spectroscopic techniques. Elemental and mass spectrometry analyses of the solid complex fit to the composition [Pt(C 6 H 11 NO 2 S)Cl 2 ]·H 2 O. 13 C NMR, 15 N NMR and infrared spectra of the complex are co...

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Bibliographic Details
Published in:Journal of coordination chemistry 2006-07, Vol.59 (10), p.1101-1106
Main Authors: Corbi, Pedro P., Massabni, Antonio C., Costa-Neto, Claudio M.
Format: Article
Language:English
Subjects:
Cancer therapy
Deoxyalliin
N NMR
Platinum(II)
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Summary:A new platinum(II) complex with deoxyalliin was synthesized and characterized by chemical and spectroscopic techniques. Elemental and mass spectrometry analyses of the solid complex fit to the composition [Pt(C 6 H 11 NO 2 S)Cl 2 ]·H 2 O. 13 C NMR, 15 N NMR and infrared spectra of the complex are consistent with coordination of deoxyalliin to Pt(II) through the nitrogen and sulfur atoms forming a square-planar geometry. The complex is soluble in dimethylsulfoxide. Biological analysis for evaluation of a potential cytotoxic effect of the complex was performed using HeLa cells, a human cervix adenocarcinoma-derived cell line. The results were compared with those of a palladium(II) complex previously described.
ISSN:0095-8972
1029-0389
DOI:10.1080/00958970500452913