Ruthenium(II) complexes of 2-(2′-pyridyl)naphthoimidazole: synthesis, characterization and DNA-binding studies

The perchlorate salts of two new ruthenium(II) complexes incorporating 2-(2′-pyridyl)naphthoimidazole are synthesized in good yield. Complexes [Ru(phen) 2 (PYNI)] 2+ (phen = 1,10-phenanthroline) 1 and [Ru(dmp) 2 (PYNI)] 2+ (dmp = 2,9-dimethyl-1,10-phenanthroline, PYNI = 2-(2′-pyridyl)naphthoimidazol...

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Bibliographic Details
Published in:Journal of coordination chemistry 2008-10, Vol.61 (20), p.3213-3224
Main Authors: Liu, Yun-Jun, Mei, Wen-Jie, Lu, Jia-Zheng, Zhao, Hao-Jie, He, Li-Xin, Wu, Fu-Hai
Format: Article
Language:English
Subjects:
DNA
Ruthenuim(II) complex
Thermal denaturation
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Summary:The perchlorate salts of two new ruthenium(II) complexes incorporating 2-(2′-pyridyl)naphthoimidazole are synthesized in good yield. Complexes [Ru(phen) 2 (PYNI)] 2+ (phen = 1,10-phenanthroline) 1 and [Ru(dmp) 2 (PYNI)] 2+ (dmp = 2,9-dimethyl-1,10-phenanthroline, PYNI = 2-(2′-pyridyl)naphthoimidazole) 2 are fully characterized by elemental analysis, FAB-MS, ES-MS, 1 H NMR and cyclic voltammetric methods. The DNA-binding behavior of the complexes have been studied by spectroscopic titration, viscosity measurements and thermal denaturation. Absorption titration and thermal denaturation studies reveal that these complexes are moderately strong binders of calf-thymus DNA (CT-DNA), with their binding constants spanning the range (2.73-5.35) × 10 4 M −1 . The experimental results show that 1 interacts with calf thymus DNA (CT-DNA) by intercalative mode, while 2 binds to CT-DNA by partial intercalation.
ISSN:0095-8972
1029-0389
DOI:10.1080/00958970802017653