Synthesis, characterization, and DNA-binding of Ln(III) complexes with 2-hydroxybenzylidene-2-phenylquinoline-4-carbonylhydrazone

2-Hydroxybenzylidene-2-phenylquinoline-4-carbonylhydrazone (H 2 L) and five Ln(III) complexes, [Ln(H 2 L)(NO 3 ) 2 ]NO 3 [Ln = La (1), Pr (2), Sm (3), Eu (4), and Tb (5)], have been synthesized and characterized by 1 H NMR, elemental analysis, conductivity measurements, mass spectra, IR spectra, and...

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Bibliographic Details
Published in:Journal of coordination chemistry 2009-07, Vol.62 (13), p.2193-2202
Main Authors: Xu, Zhi Hong, Xi, Pin Xian, Chen, Feng Juan, Zeng, Zheng Zhi
Format: Article
Language:English
Subjects:
2-Hydroxybenzylidene-2-phenylquinoline-4-carbonylhydrazone
DNA binding
Groove binding mode
Rare earth complex
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Summary:2-Hydroxybenzylidene-2-phenylquinoline-4-carbonylhydrazone (H 2 L) and five Ln(III) complexes, [Ln(H 2 L)(NO 3 ) 2 ]NO 3 [Ln = La (1), Pr (2), Sm (3), Eu (4), and Tb (5)], have been synthesized and characterized by 1 H NMR, elemental analysis, conductivity measurements, mass spectra, IR spectra, and UV spectra. The interaction of these complexes with calf thymus DNA was investigated by UV absorption spectroscopy, fluorescence spectroscopy, circular dichroism spectroscopy and viscosity measurements. Results suggest that these complexes bind to DNA via groove binding.
ISSN:0095-8972
1029-0389
DOI:10.1080/00958970902773833