Polyoxometalate cobalt-gatifloxacin complex with DNA binding and antibacterial activity

An unusual inorganic-organic antibacterial complex based on polyoxometalates (POMs) and the cobalt-gatifloxacin (GT), [Co II (C 19 FH 22 N 3 O 4 ) 3 ][C 19 FH 23 N 3 O 4 ][HSiW 12 O 40 ]·23H 2 O (1), has been synthesized. Single-crystal structural analysis shows that 1 represents for the first time...

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Bibliographic Details
Published in:Journal of coordination chemistry 2014-07, Vol.67 (13), p.2257-2270
Main Authors: Liu, Hong, Zou, Yu-Long, Zhang, Lei, Liu, Jian-Xun, Song, Chao-Yu, Chai, Dong-Feng, Gao, Guang-Gang, Qiu, Yun-Feng
Format: Article
Language:English
Subjects:
Acetal resins
Antibacterial
Antibacterial materials
Antiinfectives and antibacterials
Binding
Biological
Biological activity
Cobalt
Constants
Crystal structure
Deoxyribonucleic acid
DNA
DNA binding
E coli
Escherichia coli
Fluorescence quenching
Gatifloxacin
Heteropoly anions
Polyoxometalate
Polyoxometallates
Single crystals
Staphylococcus aureus
Structural analysis
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Summary:An unusual inorganic-organic antibacterial complex based on polyoxometalates (POMs) and the cobalt-gatifloxacin (GT), [Co II (C 19 FH 22 N 3 O 4 ) 3 ][C 19 FH 23 N 3 O 4 ][HSiW 12 O 40 ]·23H 2 O (1), has been synthesized. Single-crystal structural analysis shows that 1 represents for the first time an unusual tripodal coordination style with three GT molecules coordinating to cobalt(II) by six carboxylate and hydroxyl oxygens. The biological activity of 1 has been evaluated by investigating its binding ability to calf thymus DNA (CT-DNA). UV spectrum study of 1 has shown that it can bind to CT-DNA by intercalation. The DNA-binding constant K b was 9.6 × 10 4  M L −1 , higher than that of pure GT, 3.8 × 10 4  M L −1 . Furthermore, the antibacterial activities of 1 were tested against Staphylococcus aureus and Escherichia coli, respectively, and have shown slightly lower antibacterial activity than that of free GT at the same mass concentration. If the GT component in the complexes was controlled at the same molar concentration, 1 generates the biggest antibacterial area during the Kirby-Bauer disc diffusion detection. This result indicates that the integration of heteropolyanions and GT exhibits synergistic effects on the antibacterial activity, which paves a new way to design low-cost antibacterial compound by the introduction of POMs.
ISSN:0095-8972
1029-0389
DOI:10.1080/00958972.2014.940923