Synthesis, antimicrobial properties, and theoretical analysis of benzimidazole-2-ylidene silver(I) complexes

A series of symmetrical and nonsymmetrical N,N-disubstituted benzimidazolium salts were synthesized as N-heterocyclic carbene precursors. These salts were treated with Ag 2 O to afford their corresponding mononuclear Ag(I)-NHC complexes. These compounds were characterized by spectroscopy techniques...

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Bibliographic Details
Published in:Journal of coordination chemistry 2020-07, Vol.73 (13), p.1967-1986
Main Authors: Düşünceli, Serpil Demir, Ayaz, Dilek, Üstün, Elvan, Günal, Selami, Özdemir, Namik, Dinçer, Muharrem, Özdemir, İsmail
Format: Article
Language:English
Subjects:
Antimicrobial activity
Antimicrobial agents
benzimidazolium salts
Crystal structure
Crystallography
N-heterocyclic carbene
Silver
silver NHC complexes
Single crystals
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Summary:A series of symmetrical and nonsymmetrical N,N-disubstituted benzimidazolium salts were synthesized as N-heterocyclic carbene precursors. These salts were treated with Ag 2 O to afford their corresponding mononuclear Ag(I)-NHC complexes. These compounds were characterized by spectroscopy techniques and analyzed by DFT/TDDFT and docking methods. Also, the structures of 2a and 2e were determined by single-crystal X-ray crystallography. These new Ag-NHC complexes were screened for their antibacterial activities against Gram-positive, Gram-negative bacteria, fungi, and nosocomial agents.
ISSN:0095-8972
1029-0389
DOI:10.1080/00958972.2020.1812587