The DNA- and protein-binding properties and cytotoxicity of a new copper(II) hydrazone Schiff base complex

A new monomeric copper(II) benzhydrazone complex, [Cu(L)(H 2 O)(NO 3 )] (1), has been synthesized using Schiff base derived from quinoline-2-carboxaldehyde and benzhydrazide. Complex 1 was characterized by elemental analysis, FT-IR, UV-Vis spectroscopy along with electrochemical study and single-cry...

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Bibliographic Details
Published in:Journal of coordination chemistry 2021-06, Vol.74 (9-10), p.1482-1504
Main Authors: Biswas, Niladri, Saha, Sandeepta, Biswas, Barun Kumar, Chowdhury, Manas, Rahaman, Ashikur, Junghare, Vivek, Mohapatra, Swati, Hazra, Saugata, Zangrando, Ennio, Roy Choudhury, Ruma, Roy Choudhury, Chirantan
Format: Article
Language:English
Subjects:
Anticancer properties
Binding
Chemical analysis
Coordination compounds
Copper
Copper compounds
Copper(II)
Crystallography
Cytotoxicity
DNA-/protein-binding
Fluorescence
Hydrazones
Imines
Infrared analysis
Infrared spectroscopy
Molecular docking
Proteins
Quinoline
Schiff base complex
Single crystals
Spectroscopic analysis
Spectrum analysis
Titration
Toxicity
X-ray crystal structure
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Summary:A new monomeric copper(II) benzhydrazone complex, [Cu(L)(H 2 O)(NO 3 )] (1), has been synthesized using Schiff base derived from quinoline-2-carboxaldehyde and benzhydrazide. Complex 1 was characterized by elemental analysis, FT-IR, UV-Vis spectroscopy along with electrochemical study and single-crystal X-ray crystallography. Single-crystal diffraction study of 1 indicates that the copper(II) ion adopts a distorted square pyramidal (SQP) geometry. The calf-thymus (CT) DNA-binding property of 1 has been evaluated by employing UV-vis and fluorescence spectroscopy, cyclic voltammetry and viscosity studies. The protein-binding ability of 1 was investigated by UV-vis and fluorescence spectroscopy titration using BSA and HSA. The significant interaction of 1 with CT-DNA was further supported by molecular docking approach. Finally, in vitro cytotoxicity of 1 was investigated by MTT assay on the Human Skin Carcinoma cell line A431. All these facts indicate that 1 exhibits a promising anticancer activity.
ISSN:0095-8972
1029-0389
DOI:10.1080/00958972.2021.1913128