The pro-convulsant effects of diazinon low dose in male rats under amygdala kindling

Organophosphates can damage the brain in systemic intoxication. In this study, the effects of a minimum toxic dose (MTD) of diazinon (DZ) on amygdala afterdischarge threshold (ADT), kindling acquisition and kindled seizure parameters were evaluated. Intact male rats were stereotactically implanted w...

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Published in:Drug and chemical toxicology (New York, N.Y. 1978) N.Y. 1978), 2022-03, Vol.45 (2), p.625-632
Main Authors: Saberi, Fatemeh, Bahrami, Farideh, Saberi, Mehdi, Mashhadi Akbar Boojar, Mahdi
Format: Article
Language:English
Subjects:
after discharge
Amygdala - physiology
Animals
Convulsants - pharmacology
Diazinon
Diazinon - toxicity
kindling
Kindling, Neurologic - physiology
Male
male rat
Rats
Rats, Wistar
seizure
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Summary:Organophosphates can damage the brain in systemic intoxication. In this study, the effects of a minimum toxic dose (MTD) of diazinon (DZ) on amygdala afterdischarge threshold (ADT), kindling acquisition and kindled seizure parameters were evaluated. Intact male rats were stereotactically implanted with a tripolar and two monopolar electrodes in the amygdala and dura respectively. After recovery, animals received daily either, olive oil (control), 15 or 30 mg/kg (MTD) of DZ intraperitoneally, and ADT, afterdischarge duration (ADD) at each stage (S 1 to S 5 ) of kindling and number of trials for kindling acquisition were determined daily. Also, the effect of DZ on stage 4 latency (S 4 L), ADD, stage 5 duration (S 5 D) and the activity of the red blood cholinesterase (ChE) were evaluated. The ADT was lower and the ADD was longer significantly in DZ treated group in comparison to control (p 
ISSN:0148-0545
1525-6014
DOI:10.1080/01480545.2020.1746801