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Synthesized gold nanoparticles mediated by Crassocephalum rubens extract down-regulate KIM-1/NGAL genes and inhibit oxidative stress in cadmium-induced kidney damage in rats

Cadmium (Cd) exposure induces kidney damage by mediating oxidative stress and inflammation. In this study, the role of Crassocephalum rubens-gold nanoparticles (C. rubens-AuNPs) in down-regulating kidney injury molecules-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) genes and inhib...

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Published in:Drug and chemical toxicology (New York, N.Y. 1978) N.Y. 1978), 2023-11, Vol.ahead-of-print (ahead-of-print), p.1-8
Main Authors: Adewale, Olusola Bolaji, Anadozie, Scholastica Onyebuchi, Okpiri, Regina T., Jaiyesimi, Kikelomo Folake, Owolabi, Olutunmise V., Akinlade, Oluwatobiloba, Obafemi, Tajudeen Olabisi, Osukoya, Olukemi Adetutu, Onasanya, Amos
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Language:English
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Summary:Cadmium (Cd) exposure induces kidney damage by mediating oxidative stress and inflammation. In this study, the role of Crassocephalum rubens-gold nanoparticles (C. rubens-AuNPs) in down-regulating kidney injury molecules-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) genes and inhibiting oxidative stress in Cd-induced kidney damage in rats was investigated. Thirty male Wistar rats were distributed randomly into six groups (n = 5). Group I served as control, while groups II, III, IV, and V rats were administered with 20 mg/kg b.w. cadmium chloride (CdCl 2 ) for five consecutive days. Groups III, IV, and V rats were treated, 24 h after the last dose of CdCl 2 , with silymarin, 5 mg/kg and 10 mg/kg C. rubens-AuNPs, respectively, for 14 days. Group VI rats received 10 mg/kg C. rubens-AuNPs only for 14 days. Animals were sacrificed 24 h after the last dose of the treatment. Biochemical parameters such as kidney function markers, biomarkers of nephrotoxicity, and oxidative stress markers were assayed. Results indicated that 20 mg/kg b.w. CdCl 2 caused kidney damage, as evidenced by significant (p 
ISSN:0148-0545
1525-6014
DOI:10.1080/01480545.2022.2138427