RELATION BETWEEN IMMUNOSUPPRESSIVE PGE 2 AND IL-10 TO PRO-INFLAMMATORY IL-6 IN SEMINAL PLASMA OF INFERTILE AND FERTILE MEN

In vitro studies have reported that seminal plasma of fertile men has more inhibitory mitogenic effect and higher suppressive activity on antibody-dependent cellular cytotoxicity than seminal plasma from infertile males. Is it possible that variations in the seminal plasma composition could explain...

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Bibliographic Details
Published in:Archives of andrology 2003, Vol.49 (2), p.111-116
Main Author: CAMEJO, M.I.
Format: Article
Language:English
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Summary:In vitro studies have reported that seminal plasma of fertile men has more inhibitory mitogenic effect and higher suppressive activity on antibody-dependent cellular cytotoxicity than seminal plasma from infertile males. Is it possible that variations in the seminal plasma composition could explain these results? The present study was conducted to investigate the relation between immunosuppressive PGE 2 and IL-10 to pro-inflammatory IL-6 in seminal plasma of infertile and fertile men. Utilizing specific ELISA commercial kit, semen samples from 45 infertile undiagnosed and 25 fertile men were examined for the presence of PGE 2, IL-10, and IL-6. The IL-6 concentration in seminal plasma of infertile men was significantly higher than that of fertile men ( p
ISSN:0955-3002
0148-5016
1362-3095
DOI:10.1080/01485010390129232