Vinyl-functionalized mesoporous carbon for dispersive micro-solid phase extraction of azole antifungal agents from aqueous matrices

A simple, rapid and sensitive vinyl-functionalized mesoporous carbon-based dispersive micro-solid phase extraction method has been developed for the preconcentration and quantification of azole antifungal drugs in aqueous matrices. The effects of type of adsorbent, desorption solvent, amount of adso...

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Bibliographic Details
Published in:Separation science and technology 2020-11, Vol.55 (17), p.3102-3112
Main Authors: Yahaya, Noorfatimah, Kamaruzaman, Sazlinda, Sanagi, Mohd Marsin, Wan Ibrahim, Wan Aini, Mitome, Takahito, Nishiyama, Norikazu, Nur, Hadi, Abdul Ghaffar, Zainab, Aziz, Mohd Yusmaidie, Mohamed Fauzi, Hafizuddin
Format: Article
Language:English
Subjects:
Adsorbents
Analytical methods
Antifungal agents
aqueous samples
azole drugs
Biological properties
Biological samples
Carbon
Desorption
Dispersion
Dispersive micro-solid phase extraction
Fungicides
HPLC-UV
Linearity
Solid phases
vinyl-functionalized mesoporous carbon
Water analysis
Water sampling
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Summary:A simple, rapid and sensitive vinyl-functionalized mesoporous carbon-based dispersive micro-solid phase extraction method has been developed for the preconcentration and quantification of azole antifungal drugs in aqueous matrices. The effects of type of adsorbent, desorption solvent, amount of adsorbent, pH, desorption time, salt addition and extraction time were investigated. Under the optimized conditions, the method demonstrated good linearity over the range of 1-300 µg L −1 for water sample and 5-400 µg L −1 for biological samples, low limits of detection (0.4 µg L −1 to 1.6 µg L −1 ), good analyte recoveries (89.8-113.9%) and acceptable RSDs (7.5-13.4%).
ISSN:0149-6395
1520-5754
DOI:10.1080/01496395.2019.1675699