Impact of Nutritional Status on Survival in Head and Neck Cancer Patients After Total Laryngectomy

Malnutrition is an important prognostic indicator of laryngeal squamous cell carcinoma. Retrospective study with head and neck cancer patients who underwent total laryngectomy. 243 patients of both sex were evaluated. The univariate analyses demonstrated an increased risk of death for the patients w...

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Bibliographic Details
Published in:Nutrition and cancer 2022, Vol.ahead-of-print (ahead-of-print), p.1-9
Main Authors: Santos, Adriana, Santos, Izabella Costa, dos Reis, Patrícia Fonseca, Rodrigues, Viviane Dias, Peres, Wilza Arantes Ferreira
Format: Article
Language:English
Subjects:
Cancer
Carcinoma, Squamous Cell - pathology
Confidence intervals
Head & neck cancer
Head and neck carcinoma
Head and Neck Neoplasms - radiotherapy
Head and Neck Neoplasms - surgery
Humans
Laryngeal Neoplasms - pathology
Laryngeal Neoplasms - radiotherapy
Laryngeal Neoplasms - surgery
Laryngectomy - adverse effects
Laryngectomy - methods
Malnutrition
Medical prognosis
Nutrition assessment
Nutritional Status
Patients
Prognosis
Radiation therapy
Retrospective Studies
Squamous cell carcinoma
Statistical analysis
Surgery
Survival
Survival Rate
Weight loss
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Summary:Malnutrition is an important prognostic indicator of laryngeal squamous cell carcinoma. Retrospective study with head and neck cancer patients who underwent total laryngectomy. 243 patients of both sex were evaluated. The univariate analyses demonstrated an increased risk of death for the patients with greater weight loss, hypoalbuminemia, radiotherapy as an initial treatment, salvage surgery, and radical neck dissection. In a Multivariate Cox regression, older age (p = 0.03, 95% confidence interval [CI] 1.003-1.06, hazard ratio [HR] 1.029), Nutritional Risk Index ≤100 (p = 0.008, 95% CI 1.18-3.12, HR 1.921) and adjuvant radiotherapy (p = 0.029, 95% CI 0.31-3.12, HR 0.544) demonstrated prognostic significance in survival. Nutritional status is a modifiable variable and these findings highlight the need to adoption of simple nutritional assessment methods routinely during the treatment of head and neck cancer patients, in order to help improve prognosis after surgery.
ISSN:0163-5581
1532-7914
DOI:10.1080/01635581.2021.1952446