NONINVASIVE ASSESSMENT OF PULMONARY EMPHYSEMA USING DYNAMIC CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING

Emphysema tends to be complicated by diffuse abnormalities in the pulmonary peripheral microvasculature. The aim of this study was to evaluate whether dynamic contrast-enhanced magnetic resonance imaging (MRI) could provide a valid assessment of pulmonary blood flow as an indicator of the severity o...

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Bibliographic Details
Published in:Experimental lung research 2006, Vol.32 (1-2), p.55-67
Main Authors: Morino, Shigeyuki, Toba, Toshinari, Araki, Masato, Azuma, Takashi, Tsutsumi, Sadami, Tao, Hiroyuki, Nakamura, Tatsuo, Nagayasu, Takeshi, Tagawa, Tsutomu
Format: Article
Language:English
Subjects:
animal
Animals
Biological and medical sciences
Carbon Dioxide - blood
chronic obstructive pulmonary disease (COPD)
Contrast Media - pharmacology
Dogs
dynamic contrast-enhanced MRI
elastase-induced emphysema
Emphysema - chemically induced
Emphysema - pathology
Emphysema - physiopathology
Gadolinium DTPA - pharmacology
histology
Investigative techniques, diagnostic techniques (general aspects)
Lung Volume Measurements
Magnetic Resonance Angiography - methods
Magnetic Resonance Angiography - standards
Medical sciences
Oxygen - blood
Pancreatic Elastase
Pulmonary Circulation
Pulmonary Disease, Chronic Obstructive - chemically induced
Pulmonary Disease, Chronic Obstructive - pathology
Pulmonary Disease, Chronic Obstructive - physiopathology
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Reproducibility of Results
Respiratory system
Severity of Illness Index
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Summary:Emphysema tends to be complicated by diffuse abnormalities in the pulmonary peripheral microvasculature. The aim of this study was to evaluate whether dynamic contrast-enhanced magnetic resonance imaging (MRI) could provide a valid assessment of pulmonary blood flow as an indicator of the severity of emphysema. To do this, the authors compared MRI data with the pathological findings in lung tissue. Dynamic contrast-enhanced MRI is a noninvasive method and can be used to repeatedly monitor clinicopathological severity. Using MRI clear pulmonary vascular information can be obtained easily, and the relative pulmonary blood flow in the lung parenchyma can be quantified.
ISSN:0190-2148
1521-0499
DOI:10.1080/01902140600691548