Loss of endothelial planar cell polarity and cellular clearance mechanisms in age-related macular degeneration

Apoptosis, autophagosomes, and lysosomes are lacking in the retinal pigment epithelium (RPE) of age-related macular degeneration (AMD) eyes. Necrosis, not apoptosis, appeared to be the prominent type of cell death in RPE, which led to the accumulation of cell debris within and on both sides of Bruch...

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Bibliographic Details
Published in:Ultrastructural pathology 2017-09, Vol.41 (5), p.312-319
Main Authors: Campos, Maria Mercedes, Abu-Asab, Mones S.
Format: Article
Language:English
Subjects:
Age-related macular degeneration (AMD)
Aging
apoptosis
autophagy
Bruch Membrane - ultrastructure
Bruch's membrane
Cell Polarity - physiology
choriocapillaris
Choroid - cytology
endothelial cells
Endothelial Cells - ultrastructure
Humans
lysosomes
Macular Degeneration - etiology
Macular Degeneration - therapy
necrosis
planar cell polarity (PCP)
retinal pigment epithelium (RPE)
Retinal Pigment Epithelium - ultrastructure
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Summary:Apoptosis, autophagosomes, and lysosomes are lacking in the retinal pigment epithelium (RPE) of age-related macular degeneration (AMD) eyes. Necrosis, not apoptosis, appeared to be the prominent type of cell death in RPE, which led to the accumulation of cell debris within and on both sides of Bruch's membrane. The endothelium of the choriocapillaris had an altered planar cell polarity which encompassed the disappearance of fenestrations, the thickening of cytoplasm, and anterior nuclear dislocation. There were no significant differences in RPE and choroidal aberrations between macular and temporal regions. Loss of endothelial polarity could be at the crux of AMD initiation and progression.
ISSN:0191-3123
1521-0758
DOI:10.1080/01913123.2017.1348418