Tannic acid-coated zeolite Y nanoparticles as novel drug nanocarrier with controlled release behavior and anti-protozoan activity against Trichomonas gallinae

In this study, a pH-sensitive drug release system was prepared by zeolite Y nanoparticles and tannic acid. Zeolite Y nanoparticles were synthesized via hydrothermal synthesis of colloidal suspensions and after that, were coated with tannic acid. In order to evaluate its performance, metronidazole as...

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Bibliographic Details
Published in:Journal of dispersion science and technology 2019-04, Vol.40 (4), p.587-593
Main Authors: Rezaee, Hosna, Ghorbani, Mohsen, Nikpay, Ali, Soltani, Maryam
Format: Article
Language:English
Subjects:
Acids
Controlled release
Drug delivery
Drug delivery systems
Maltose
metronidazole
Nanocomposites
Nanoparticles
Tannic acid
trichomonas gallinae
Yeast
zeolite Y
Zeolites
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Summary:In this study, a pH-sensitive drug release system was prepared by zeolite Y nanoparticles and tannic acid. Zeolite Y nanoparticles were synthesized via hydrothermal synthesis of colloidal suspensions and after that, were coated with tannic acid. In order to evaluate its performance, metronidazole as an anti-protozoan drug was loaded into nanocarriers via immersing method to study the in-vitro drug delivery behavior. This nanocomposite carriers represented pH-sensitive behavior and had more and faster release in acidic medium. In-vitro effects of metronidazole-loaded nanoparticles was measured against Trichomonas gallinae trophozoites in Trypticase Yeast extract Maltose medium. The results suggested that metronidazole-loaded and tannic acid-modified zeolite Y nanoparticles could be a potential anti-trichomonal agent.
ISSN:0193-2691
1532-2351
DOI:10.1080/01932691.2018.1475240