Effects of the characteristics of chitosan on controlling drug release of chitosan coated PLLA microspheres

Chitosan has been shown to be a biomaterial with good biocompatibility, and is highly biodegradable. This study investigated the effect of post-coating PLLA microspheres with different chitosans on the initial burst and controlling the drug release of the microspheres. Without chitosan, 19.2% of enc...

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Bibliographic Details
Published in:Journal of microencapsulation 2001, Vol.18 (5), p.613-625
Main Authors: CHIOU, S.-H, WU, W.-T, HUANG, Y.-Y, CHUNG, T.-W
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chitin - administration & dosage
Chitin - analogs & derivatives
Chitosan
Chitosan Plla Microsphere Controlled Drug Release
Drug Delivery Systems
General pharmacology
Medical sciences
Microspheres
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polyesters - administration & dosage
Viscosity
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Summary:Chitosan has been shown to be a biomaterial with good biocompatibility, and is highly biodegradable. This study investigated the effect of post-coating PLLA microspheres with different chitosans on the initial burst and controlling the drug release of the microspheres. Without chitosan, 19.2% of encapsulated lidocaine would release from PLLA microspheres within the first hour (R1), and the time of 50% release (T50
ISSN:0265-2048
1464-5246
DOI:10.1080/02652040010019497