Mesoporous particle-based microcontainers for intranasal delivery of imidazopyridine drugs

The aim of this study was to develop mesoporous containers for entrapment of imidazopyridines, such as sedative-hypnotic medicine zolpidem, anxiolytic agent alpidem and their derivatives. For this purpose, calcium carbonate (size 1.2 µm (PDI: 0.6), zeta potential: −10 mV), manganese carbonate (2.5 µ...

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Bibliographic Details
Published in:Journal of microencapsulation 2018-11, Vol.35 (7-8), p.657-666
Main Authors: Marchenko, Irina, Borodina, Tatiana, Trushina, Daria, Rassokhina, Irina, Volkova, Yulia, Shirinian, Valerii, Zavarzin, Igor, Gogin, Andrey, Bukreeva, Tatiana
Format: Article
Language:English
Subjects:
drug delivery
imidazopyridines
intranasal delivery
Mesoporous particles
microcontainers
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Summary:The aim of this study was to develop mesoporous containers for entrapment of imidazopyridines, such as sedative-hypnotic medicine zolpidem, anxiolytic agent alpidem and their derivatives. For this purpose, calcium carbonate (size 1.2 µm (PDI: 0.6), zeta potential: −10 mV), manganese carbonate (2.5 µm (PDI: 0.5), zeta potential: −12 mV) and titanium dioxide particles (3.7 µm (PDI: 0.4), zeta potential: −15 mV) were used. The compounds were encapsulated applying two techniques: adsorption on the preformed particles and co-precipitation during the synthesis of the particles. The polymer shell of the containers was formed by electrostatic adsorption of polyelectrolytes on the surface of the particles. The best encapsulation efficacy was shown for zolpidem incorporated into calcium carbonate (5.4%) and manganese carbonate (4.6%) by adsorption. Release of the compounds from the containers based on the proposed particles were characterised by the short time burst effect (
ISSN:0265-2048
1464-5246
DOI:10.1080/02652048.2019.1571642