Development of folic acid-loaded nanostructured lipid carriers for topical delivery: preparation, characterisation and ex vivo investigation

The present work is designed to achieve efficient localised skin delivery of folic acid (FA)-loaded nanostructured lipid carriers (NLCs) to infer efficient treatment of skin photoageing conditions induced via excessive exposure to ultraviolet (UV) radiation. FA NLCs were prepared by high-speed homog...

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Bibliographic Details
Published in:Journal of microencapsulation 2020-07, Vol.37 (5), p.366-383
Main Authors: Ammar, Hussein Osman, Ghorab, Mahmoud Mohamed, Mostafa, Dina Mahmoud, Abd El-Alim, Sameh Hosam, Kassem, Ahmed Alaa, Salah, Salwa, Shalaby, Eman Samy
Format: Article
Language:English
Subjects:
Folic acid
nanostructured lipid carrier
occlusion
skin deposition
skin permeation
spreadability
topical delivery
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Summary:The present work is designed to achieve efficient localised skin delivery of folic acid (FA)-loaded nanostructured lipid carriers (NLCs) to infer efficient treatment of skin photoageing conditions induced via excessive exposure to ultraviolet (UV) radiation. FA NLCs were prepared by high-speed homogenisation followed by ultrasonication. The obtained NLCs revealed high encapsulation efficiencies (89.42-99.26%) with nanometric particle sizes (27.06-85.36 nm) of monodisperse distribution (PDI = 0.137-0.442), zeta potential values >|27| mV, pseudoplastic rheological behaviour, good spreadability (2.25-3.30 cm) and promoted occlusive properties throughout 48 h. Optimised NLC formulations appeared as sphere-shaped particles using transmission electron microscopy, showed improved photostability of FA and prolonged in vitro release profile best fitted to Higuchi diffusion model. Ex vivo permeation and deposition of FA, employing Wistar rat skins, depicted enhanced permeability and existence of FA in skin layers after 6 h. Based on the obtained results, FA-loaded NLC formulations demonstrate a promising modality for anti-photoageing therapy.
ISSN:0265-2048
1464-5246
DOI:10.1080/02652048.2020.1761904