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Impact of age on acute post-TBI neuropathology in mice expressing humanized tau: a Chronic Effects of Neurotrauma Consortium Study

Objectives: We hypothesized that polypathology is more severe in older than younger mice during the acute phase following repetitive mild traumatic brain injury (r-mTBI). Methods: Young and aged male and female mice transgenic for human tau (hTau) were exposed to r-mTBI or a sham procedure. Twenty-f...

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Published in:Brain injury 2018-08, Vol.32 (10), p.1285-1294
Main Authors: Mouzon, Benoit, Saltiel, Nicole, Ferguson, Scott, Ojo, Joseph, Lungmus, Carlyn, Lynch, Cillian, Algamal, Moustafa, Morin, Alexander, Carper, Benjamin, Bieler, Gayle, Mufson, Elliott J., Stewart, William, Mullan, Michael, Crawford, Fiona
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container_issue 10
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container_title Brain injury
container_volume 32
creator Mouzon, Benoit
Saltiel, Nicole
Ferguson, Scott
Ojo, Joseph
Lungmus, Carlyn
Lynch, Cillian
Algamal, Moustafa
Morin, Alexander
Carper, Benjamin
Bieler, Gayle
Mufson, Elliott J.
Stewart, William
Mullan, Michael
Crawford, Fiona
description Objectives: We hypothesized that polypathology is more severe in older than younger mice during the acute phase following repetitive mild traumatic brain injury (r-mTBI). Methods: Young and aged male and female mice transgenic for human tau (hTau) were exposed to r-mTBI or a sham procedure. Twenty-four hours post-last injury, mouse brain tissue was immunostained for alterations in astrogliosis, microgliosis, tau pathology, and axonal injury. Results: Quantitative analysis revealed a greater percent distribution of glial fibrillary acid protein and Iba-1 reactivity in the brains of all mice exposed to r-mTBI compared to sham controls. With respect to axonal injury, the number of amyloid precursor protein-positive profiles was increased in young vs aged mice post r-mTBI. An increase in tau immunoreactivity was found in young and aged injured male hTau mice. Conclusions: We report the first evidence in our model that r-mTBI precipitates a complex sequelae of events in aged vs young hTau mice at an acute time point, typified by an increase in phosphorylated tau and astroglisosis, and a diminished microgliosis response and axonal injury in aged mice. These findings suggest differential age-dependent effects in TBI pathobiology.
doi_str_mv 10.1080/02699052.2018.1486457
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source Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)
subjects age
animal models
axonal injury
inflammation
neurodegeneration
tau
Traumatic Brain Injury
title Impact of age on acute post-TBI neuropathology in mice expressing humanized tau: a Chronic Effects of Neurotrauma Consortium Study
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