Hyperosmolar therapies for neurological deterioration in mild and moderate traumatic brain injury: A scoping review

To explore the available evidence on hyperosmolar therapies(HT) in mild and moderate traumatic brain injury(TBI) and to evaluate the effects on outcomes. A scoping review was conducted according to the Joanna Briggs Institute methodology. Inclusion criteria: (a)randomized controlled trials(RCTs), pr...

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Bibliographic Details
Published in:Brain injury 2023-07, Vol.37 (9), p.1107-1115
Main Authors: Marchesini, Nicolò, Fernández Londoño, Laura Lucía, Boaro, Alessandro, Kuhn, Isla, Griswold, Dylan, Sala, Francesco, Rubiano, Andrés M.
Format: Article
Language:English
Subjects:
Adult
Brain Concussion - complications
brain injuries
Brain Injuries, Traumatic - complications
Brain Injuries, Traumatic - drug therapy
Child
Glasgow Coma Scale
Humans
hyperosmolar
Neurotrauma
outcome
Prospective Studies
Retrospective Studies
Saline Solution, Hypertonic - therapeutic use
TBI
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Summary:To explore the available evidence on hyperosmolar therapies(HT) in mild and moderate traumatic brain injury(TBI) and to evaluate the effects on outcomes. A scoping review was conducted according to the Joanna Briggs Institute methodology. Inclusion criteria: (a)randomized controlled trials(RCTs), prospective and retrospective cohort studies and case-control studies; (b)all-ages mild and moderate TBIs; (c)HT administration; (d)functional outcomes recorded; (e)comparator group. From 4424 records, only 3 respected the inclusion criteria. In a retrospective cohort study of adult moderate TBIs, the Glasgow Coma Scale(GCS) remained the same at 48 hours in those treated with hypertonic saline(HTS) while it worsened in the non-treated. A trend toward increased pulmonary infections and length of stay was found. In an RCT of adult severe and moderate TBIs, moderate TBIs treated with HTS showed a trend toward better secondary outcomes than standard care alone, with similar odds of adverse effects. An RCT enrolling children with mild TBI found a significant improvement in concussive pain immediately after HTS administration and after 2-3 days. No adverse events occurred. A gap in the literature about HTs' role in mild and moderate TBI was found. Some benefits may exist with limited side effects and further studies are desirable.
ISSN:0269-9052
1362-301X
DOI:10.1080/02699052.2023.2191010