Corpus striatum and traumatic brain injury

The possibility of a subcortical syndrome differentially affecting memory in traumatic brian injury TBI subjects was examined. Magnetic resonance imaging scans of 46 traumatic brain injured male patients were compared with those of 34 male control subjects. Surface area measurements of the corpus st...

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Bibliographic Details
Published in:Brain injury 1997-08, Vol.11 (8), p.577-586
Main Authors: PRIMUS, E. A, BIGLER, E. D, ANDERSON, C. V, JOHNSON, S. C, MUELLER, R. M, BLATTER, D
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Brain Injuries - complications
Brain Injuries - pathology
Cognition Disorders - diagnosis
Cognition Disorders - etiology
Corpus Striatum - pathology
Humans
Injuries of the nervous system and the skull. Diseases due to physical agents
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Neuropsychological Tests
Severity of Illness Index
Traumas. Diseases due to physical agents
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Summary:The possibility of a subcortical syndrome differentially affecting memory in traumatic brian injury TBI subjects was examined. Magnetic resonance imaging scans of 46 traumatic brain injured male patients were compared with those of 34 male control subjects. Surface area measurements of the corpus striatum were calculated for both groups. Results demonstrated no significant differences in corpus striatum surface area measurements. Additionally, TBI patients were grouped according to severity of injury, as well as degree of corpus striatum atrophy, and neuropsychological outcome was examined. There were modest (r=0.35) but significant correlations between corpus striatum degeneration and the delayed recall trial and total score of the Rey Auditory Verbal Learning Test, but no other correlations between neuropsychological and corpus striatal surface area were significant. Because subcortical pathology may have a differential effect on memory, recognition and recall memory were further analysed, but no significant differences were found. TBI subjects with the smallest corpus striatum values did not test significantly different from TBI patients with normal corpus striatum values or differences in cortical atrophy, as determined by a ventricle to brain ratio. These findings suggest that there is not a unique pattern of subcortical pathology involving the corpus striatum in TBI.
ISSN:0269-9052
1362-301X
DOI:10.1080/026990597123278