Effects of Postural Variation on Intra-ocular Pressure: Comparison between Pseudo-exfoliation Glaucoma and Primary Open Angle Glaucoma

• Published in: Current eye research 2020-10, Vol.45 (10), p.1309-1314
• Main Authors: Dar, Nimrod, Belkin, Avner, Pillar, Shani, Sheiman, Vadim, Tempelhof, Ortal F., Barkana, Yaniv, Geffen, Noa
• Format: Article
• Language: English
• Subjects: Posture-related IOP changes; primary open-angle glaucoma; pseudo-exfoliation glaucoma; trabeculectomy
• ISSN: 0271-3683; 1460-2202
• DOI: 10.1080/02713683.2020.1739313

Purpose: to compare the posture-related intraocular pressure (IOP) changes in pseudo-exfoliation glaucoma (PXFG) and in primary open-angle glaucoma (POAG) patients using the EyeOP, a novel Goldmann Applanation Tonometer (GAT) and to investigate the effect of ab externo trabeculectomy on these changes. Methods: Prospective, non-randomized, controlled, observational study. IOP was measured in sitting and in left lateral decubitus positions (LLDP), using GAT, GAT-EyeOP and Tonopen XL. Main Outcome Measure: Posture-related IOP differences between groups. Results: Thirty-two eyes of 32 PXFG patients (21 non-operated, 11 post-trabeculectomy) and 47 eyes of 47 POAG patients (18 non-operated, 29 post-trabeculectomy) were included. Among non-operated patients, the average increase in GAT IOP between positions (∆IOP) was 2 ± 1.86 mmHg for the PXFG group and 1.9 ± 2.84 mmHg for the POAG group (P = .87). The ∆IOP among operated patients (1.72 ± 1.9) was slightly less than in non-operated (1.6 ± 2.69; P = .905). Generally, in the LLDP, the mean difference between GAT and Tonopen XL IOP measurements was 1.9 ± 3.83 mmHg (r = 0.643; P