Experimental short-term tolerance to perfluorodecalin in the rabbit eye: a histopathological study

Purpose. Perfluorocarbon liquids are largely used in vitreoretinal surgery, but their permanence into the eye is considered harmful and early withdrawal is routinely performed by most of the surgeons. We undertook this investigation to evaluate the effects of Perfluorodecalin (PFD) tamponade followi...

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Bibliographic Details
Published in:Current eye research 1998-08, Vol.17 (8), p.828-835
Main Authors: Migliavacca, Luca, Bottoni, Ferdinando, Miglior, Stefano
Format: Article
Language:English
Subjects:
Animals
experimental model
Fluorocarbons - pharmacology
Fluorocarbons - toxicity
Male
perfluorocarbon liquids
perfluorodecalin
rabbit
Rabbits
Retina
Retina - drug effects
Retina - ultrastructure
Retinal Diseases - chemically induced
Retinal Diseases - pathology
Specific Gravity
Time Factors
Vitrectomy
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Summary:Purpose. Perfluorocarbon liquids are largely used in vitreoretinal surgery, but their permanence into the eye is considered harmful and early withdrawal is routinely performed by most of the surgeons. We undertook this investigation to evaluate the effects of Perfluorodecalin (PFD) tamponade following vitrectomy in the rabbit eye. Methods. Twenty-four rabbits underwent vitrectomy of the right eye according with a standard procedure. Eighteen rabbits received PFD and 6 control rabbits received Balanced Salt Solution (BSS) as vitreous substitute. The eyes were examined with light microscopy and transmission electron microscopy after two, four and six days after tamponade and thirty days after the withdrawal of PFD. Results. The tamponade lasting four or more days caused irreversible retinal damage involving the photoreceptors and retinal pigment epithelium. Peculiar impressions were formed in the inner retina at the site of the gravitational effect of PFD droplets. Conclusions. Based on the results of this study we suggest that the tamponade with PFD lasting more than two days is detrimental to the retina, at least in the case of the rabbit. Damage seems to be related only to the high specific gravity of PFD. Curr. Eye Res. 17:828-835, 1998.
ISSN:0271-3683
1460-2202
DOI:10.1080/02713689808951265