Evaluation of hemato-biochemical, antioxidant enzymes as biochemical biomarkers and genotoxic potential of glyphosate in freshwater fish (Labeo rohita)

Glyphosate, an herbicide is extensively used in aquaculture and agriculture to control unwanted weeds, the exact mechanism of its toxicity in freshwater fish is not exactly understood. Therefore, the current study examined the mechanisms of toxicity of glyphosate in Labeo rohita. Labeo rohita were r...

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Bibliographic Details
Published in:Chemistry and ecology 2021-08, Vol.37 (7), p.646-667
Main Authors: Ghaffar, Abdul, Hussain, Riaz, Ahmad, Noman, Ghafoor, Riaz, Akram, Muhammad Waseem, Khan, Iahtasham, Khan, Ahrar
Format: Article
Language:English
Subjects:
Abnormalities
Animal tissues
antioxidant enzymes genotoxicity
Antioxidants
Aquaculture
Biochemistry
Biomarkers
Blood cells
Blood levels
Catalase
DNA
DNA damage
Enzymes
Epithelial cells
Epithelium
Erythrocytes
Fish
Freshwater
Freshwater fish
Freshwater fishes
Genotoxicity
Gills
Glyphosate
Hemoglobin
Herbicides
histopathology
Inland water environment
Kidneys
Labeo rohita
Lamellae
Liver
Lymphocytes
Malformations
Monocytes
Necrosis
Oxidative stress
Time response
Tissue
Toxicity
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Summary:Glyphosate, an herbicide is extensively used in aquaculture and agriculture to control unwanted weeds, the exact mechanism of its toxicity in freshwater fish is not exactly understood. Therefore, the current study examined the mechanisms of toxicity of glyphosate in Labeo rohita. Labeo rohita were randomly divided into five groups and were exposed to glyphosate. Glyphosate-treated fish exhibited clinical and behavioural ailments. Microscopically, different gills of exposed fish indicated necrosis of epithelial cells of the primary and secondary lamellae, congestion, atrophied lamellae, and uplifting of lamellae. Kidneys and livers of intoxicated fish exhibited different degenerative abnormalities. Red blood cells, haemoglobin concentration, lymphocytes, and monocytes count decreased significantly (p 
ISSN:0275-7540
1029-0370
DOI:10.1080/02757540.2021.1937141