Alterations of serum and saliva oxidative markers in patients with bronchial asthma

The development of asthma is highly affected by exposure to exogenous and endogenous oxidative molecules, but the impact of this exposure on the pathophysiology of asthma has received little attention. Evaluating group of selective oxidative stress markers as a tool in the management of asthma disea...

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Bibliographic Details
Published in:The Journal of asthma 2022-11, Vol.59 (11), p.2154-2161
Main Authors: Abboud, Muayad M., Al-Rawashde, Futoon A., Al-Zayadneh, Enas M.
Format: Article
Language:English
Subjects:
adult asthma
Antioxidants
Asthma - diagnosis
asthma severity
Biomarkers - metabolism
Catalase
childhood asthma
Glutathione
Glutathione Peroxidase
Humans
Malondialdehyde
Oxidants
Oxidative markers
Oxidative Stress - physiology
Saliva
Superoxide Dismutase
Uric Acid
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Summary:The development of asthma is highly affected by exposure to exogenous and endogenous oxidative molecules, but the impact of this exposure on the pathophysiology of asthma has received little attention. Evaluating group of selective oxidative stress markers as a tool in the management of asthma disease. In comparison with matched healthy controls, levels of the oxidant and antioxidant markers: lipid peroxidation malondialdehyde (MDA), Total glutathione (tGSH), Uric acid (UA), Glutathione peroxidase (GPx), Catalase (CAT) superoxide dismutase (SOD), and Total antioxidant capacity (TAC) were assessed in serum and saliva of different asthma groups. All oxidative markers in serum and saliva of asthma patients showed significant alterations from normal healthy controls (P 
ISSN:0277-0903
1532-4303
DOI:10.1080/02770903.2021.2008426