Use of MicroRNA biomarkers to distinguish enchondroma from low-grade chondrosarcoma

Establishing a definitive diagnosis between benign enchondroma versus low-grade chondrosarcoma presents a potential challenge to both clinicians and pathologists. microRNAs (small non-coding RNAs) have proven to be effective biomarkers for the identification of tumors and tumor progression. We prese...

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Bibliographic Details
Published in:Connective tissue research 2017-03, Vol.58 (2), p.155-161
Main Authors: Zhang, Liang, Yang, Maozhou, Mayer, Theodore, Johnstone, Brian, Les, Clifford, Frisch, Nicholas, Parsons, Theodore, Mi, Qing-Sheng, Gibson, Gary
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - biosynthesis
Biomarkers, Tumor - genetics
Chondroma - diagnosis
Chondroma - genetics
Chondroma - metabolism
Chondroma - pathology
chondrosarcoma
Chondrosarcoma - diagnosis
Chondrosarcoma - genetics
Chondrosarcoma - metabolism
Chondrosarcoma - pathology
enchondroma
Female
Humans
Male
microRNA
MicroRNAs - biosynthesis
MicroRNAs - genetics
Middle Aged
miR-138
miR-181a
RNA, Neoplasm - biosynthesis
RNA, Neoplasm - genetics
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Summary:Establishing a definitive diagnosis between benign enchondroma versus low-grade chondrosarcoma presents a potential challenge to both clinicians and pathologists. microRNAs (small non-coding RNAs) have proven to be effective biomarkers for the identification of tumors and tumor progression. We present analysis, both array and quantitative PCR, that shows consistently and substantially increased expression of two microRNAs, miRs-181a and -138, in low-grade chondrosarcomas compared with enchondromas. The data suggest these microRNAs would provide an analytical distinction between the chondrosarcoma and benign neoplasms that can be performed in formalin-fixed paraffin-embedded specimens. Together with recent publications, these data indicate that miRs-181a and -138 also play a role in tumor development and homeostasis and may provide new targets for the development of much needed therapeutic intervention.
ISSN:0300-8207
1607-8438
DOI:10.1080/03008207.2016.1197212