Characterization of the antigenic, immunogenic, and pathogenic variation of infectious bursal disease virus due to propagation in different host systems (bursa, embryo, and cell culture). III. Pathogenicity

Differences in the relative pathogenicity of variant (1084 E and GLS) and standard (Edgar and STC) infectious bursal disease virus (IBDV) strains were observed after propagation in the bursa of Fabricius, embryos, or cell cultures. Bursa-derived IBDV induced the most severe lesions in the bursa of F...

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Bibliographic Details
Published in:Avian pathology 2002-10, Vol.31 (5), p.485-492
Main Authors: Rodriguez-Chavez, Isaac R., Rosenberger, John K., Cloud, Sandra S., Pope, Conrad R.
Format: Article
Language:English
Subjects:
Animals
Birnaviridae Infections - immunology
Birnaviridae Infections - pathology
Birnaviridae Infections - veterinary
Bursa of Fabricius - immunology
Bursa of Fabricius - pathology
Cells, Cultured
Chick Embryo - virology
Chickens
Infectious bursal disease virus - growth & development
Infectious bursal disease virus - immunology
Infectious bursal disease virus - pathogenicity
Poultry Diseases - immunology
Poultry Diseases - pathology
Virulence
Virus Replication
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Summary:Differences in the relative pathogenicity of variant (1084 E and GLS) and standard (Edgar and STC) infectious bursal disease virus (IBDV) strains were observed after propagation in the bursa of Fabricius, embryos, or cell cultures. Bursa-derived IBDV induced the most severe lesions in the bursa of Fabricius when compared with strains propagated in embryos or cell cultures. Embryo-derived IBDV induced moderate gross bursal lesions, whereas cell culture-derived IBDV did not damage the bursa grossly. A high frequency of virus re-isolations was obtained from bursal, spleen, and thymic samples collected from birds inoculated with bursa-derived or embryo-derived IBDV. Virus re-isolation occurred much less frequently from birds inoculated with cell culture-adapted IBDV. Serological evaluations demonstrated that bursa-derived IBDV strains induced a higher neutralizing antibody response than did embryo-derived or cell culture-derived strains. These results document that the relative pathogenicity and immunogenicity of IBDV is reduced following propagation in embryos or cell cultures.
ISSN:0307-9457
1465-3338
DOI:10.1080/0307945021000005851