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Characterization of the antigenic, immunogenic, and pathogenic variation of infectious bursal disease virus due to propagation in different host systems (bursa, embryo, and cell culture). III. Pathogenicity
Differences in the relative pathogenicity of variant (1084 E and GLS) and standard (Edgar and STC) infectious bursal disease virus (IBDV) strains were observed after propagation in the bursa of Fabricius, embryos, or cell cultures. Bursa-derived IBDV induced the most severe lesions in the bursa of F...
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| Published in: | Avian pathology 2002-10, Vol.31 (5), p.485-492 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c482t-95740fff54db53d0e4245134acddc45e7090f5e06cc470349f9412ed4fce81263 |
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| cites | cdi_FETCH-LOGICAL-c482t-95740fff54db53d0e4245134acddc45e7090f5e06cc470349f9412ed4fce81263 |
| container_end_page | 492 |
| container_issue | 5 |
| container_start_page | 485 |
| container_title | Avian pathology |
| container_volume | 31 |
| creator | Rodriguez-Chavez, Isaac R. Rosenberger, John K. Cloud, Sandra S. Pope, Conrad R. |
| description | Differences in the relative pathogenicity of variant (1084 E and GLS) and standard (Edgar and STC) infectious bursal disease virus (IBDV) strains were observed after propagation in the bursa of Fabricius, embryos, or cell cultures. Bursa-derived IBDV induced the most severe lesions in the bursa of Fabricius when compared with strains propagated in embryos or cell cultures. Embryo-derived IBDV induced moderate gross bursal lesions, whereas cell culture-derived IBDV did not damage the bursa grossly. A high frequency of virus re-isolations was obtained from bursal, spleen, and thymic samples collected from birds inoculated with bursa-derived or embryo-derived IBDV. Virus re-isolation occurred much less frequently from birds inoculated with cell culture-adapted IBDV. Serological evaluations demonstrated that bursa-derived IBDV strains induced a higher neutralizing antibody response than did embryo-derived or cell culture-derived strains. These results document that the relative pathogenicity and immunogenicity of IBDV is reduced following propagation in embryos or cell cultures. |
| doi_str_mv | 10.1080/0307945021000005851 |
| format | article |
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A high frequency of virus re-isolations was obtained from bursal, spleen, and thymic samples collected from birds inoculated with bursa-derived or embryo-derived IBDV. Virus re-isolation occurred much less frequently from birds inoculated with cell culture-adapted IBDV. Serological evaluations demonstrated that bursa-derived IBDV strains induced a higher neutralizing antibody response than did embryo-derived or cell culture-derived strains. These results document that the relative pathogenicity and immunogenicity of IBDV is reduced following propagation in embryos or cell cultures.</description><identifier>ISSN: 0307-9457</identifier><identifier>EISSN: 1465-3338</identifier><identifier>DOI: 10.1080/0307945021000005851</identifier><identifier>PMID: 12427342</identifier><language>eng</language><publisher>England: Taylor & Francis Group</publisher><subject>Animals ; Birnaviridae Infections - immunology ; Birnaviridae Infections - pathology ; Birnaviridae Infections - veterinary ; Bursa of Fabricius - immunology ; Bursa of Fabricius - pathology ; Cells, Cultured ; Chick Embryo - virology ; Chickens ; Infectious bursal disease virus - growth & development ; Infectious bursal disease virus - immunology ; Infectious bursal disease virus - pathogenicity ; Poultry Diseases - immunology ; Poultry Diseases - pathology ; Virulence ; Virus Replication</subject><ispartof>Avian pathology, 2002-10, Vol.31 (5), p.485-492</ispartof><rights>Copyright Taylor & Francis Group, LLC 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-95740fff54db53d0e4245134acddc45e7090f5e06cc470349f9412ed4fce81263</citedby><cites>FETCH-LOGICAL-c482t-95740fff54db53d0e4245134acddc45e7090f5e06cc470349f9412ed4fce81263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12427342$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodriguez-Chavez, Isaac R.</creatorcontrib><creatorcontrib>Rosenberger, John K.</creatorcontrib><creatorcontrib>Cloud, Sandra S.</creatorcontrib><creatorcontrib>Pope, Conrad R.</creatorcontrib><title>Characterization of the antigenic, immunogenic, and pathogenic variation of infectious bursal disease virus due to propagation in different host systems (bursa, embryo, and cell culture). III. Pathogenicity</title><title>Avian pathology</title><addtitle>Avian Pathol</addtitle><description>Differences in the relative pathogenicity of variant (1084 E and GLS) and standard (Edgar and STC) infectious bursal disease virus (IBDV) strains were observed after propagation in the bursa of Fabricius, embryos, or cell cultures. Bursa-derived IBDV induced the most severe lesions in the bursa of Fabricius when compared with strains propagated in embryos or cell cultures. Embryo-derived IBDV induced moderate gross bursal lesions, whereas cell culture-derived IBDV did not damage the bursa grossly. A high frequency of virus re-isolations was obtained from bursal, spleen, and thymic samples collected from birds inoculated with bursa-derived or embryo-derived IBDV. Virus re-isolation occurred much less frequently from birds inoculated with cell culture-adapted IBDV. Serological evaluations demonstrated that bursa-derived IBDV strains induced a higher neutralizing antibody response than did embryo-derived or cell culture-derived strains. These results document that the relative pathogenicity and immunogenicity of IBDV is reduced following propagation in embryos or cell cultures.</description><subject>Animals</subject><subject>Birnaviridae Infections - immunology</subject><subject>Birnaviridae Infections - pathology</subject><subject>Birnaviridae Infections - veterinary</subject><subject>Bursa of Fabricius - immunology</subject><subject>Bursa of Fabricius - pathology</subject><subject>Cells, Cultured</subject><subject>Chick Embryo - virology</subject><subject>Chickens</subject><subject>Infectious bursal disease virus - growth & development</subject><subject>Infectious bursal disease virus - immunology</subject><subject>Infectious bursal disease virus - pathogenicity</subject><subject>Poultry Diseases - immunology</subject><subject>Poultry Diseases - pathology</subject><subject>Virulence</subject><subject>Virus Replication</subject><issn>0307-9457</issn><issn>1465-3338</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNqFkduKFDEQhoMo7rj6BILkShS2xxz7cLMgg4eBBb3Q6yaTVHYi3cmYpFfbh_SZzNjDerO4uQlVfP9fVfwIPadkTUlL3hBOmk5Iwig5PtlK-gCtqKhlxTlvH6LVkagK0pyhJyl9K1AtJXuMzigTrOGCrdDvzV5FpTNE90tlFzwOFuc9YOWzuwbv9AV24zj5cCqUN_ig8n6p8Y2K7lbnvAVdiinh3RSTGrBxCVQCfONiaZoJcA74EMNBXS8q5wtjLUTwGe9DyjjNKcOY8Ku_FhcYxl2cwzJYwzBgPQ15ivB6jbfb7Rp_vl3G5fkpemTVkODZ6T9HX9-_-7L5WF19-rDdvL2qtGhZrjrZCGKtlcLsJDcEBBOScqG0MVpIaEhHrARSay0awkVnO0EZGGE1tJTV_By9XHzLLd8nSLkfXTpupzyU8_uG1U3XFOl9IG2bum4JLyBfQB1DShFsf4huVHHuKemPefd35F1UL072024E809zCrgAlwtQsglxVD9CHEyf1TyEaKPy2qWe_39Cd6_BHbo-_8z8D10hz5s</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>Rodriguez-Chavez, Isaac R.</creator><creator>Rosenberger, John K.</creator><creator>Cloud, Sandra S.</creator><creator>Pope, Conrad R.</creator><general>Taylor & Francis Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20021001</creationdate><title>Characterization of the antigenic, immunogenic, and pathogenic variation of infectious bursal disease virus due to propagation in different host systems (bursa, embryo, and cell culture). III. Pathogenicity</title><author>Rodriguez-Chavez, Isaac R. ; Rosenberger, John K. ; Cloud, Sandra S. ; Pope, Conrad R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-95740fff54db53d0e4245134acddc45e7090f5e06cc470349f9412ed4fce81263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Birnaviridae Infections - immunology</topic><topic>Birnaviridae Infections - pathology</topic><topic>Birnaviridae Infections - veterinary</topic><topic>Bursa of Fabricius - immunology</topic><topic>Bursa of Fabricius - pathology</topic><topic>Cells, Cultured</topic><topic>Chick Embryo - virology</topic><topic>Chickens</topic><topic>Infectious bursal disease virus - growth & development</topic><topic>Infectious bursal disease virus - immunology</topic><topic>Infectious bursal disease virus - pathogenicity</topic><topic>Poultry Diseases - immunology</topic><topic>Poultry Diseases - pathology</topic><topic>Virulence</topic><topic>Virus Replication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodriguez-Chavez, Isaac R.</creatorcontrib><creatorcontrib>Rosenberger, John K.</creatorcontrib><creatorcontrib>Cloud, Sandra S.</creatorcontrib><creatorcontrib>Pope, Conrad R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Avian pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodriguez-Chavez, Isaac R.</au><au>Rosenberger, John K.</au><au>Cloud, Sandra S.</au><au>Pope, Conrad R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of the antigenic, immunogenic, and pathogenic variation of infectious bursal disease virus due to propagation in different host systems (bursa, embryo, and cell culture). III. Pathogenicity</atitle><jtitle>Avian pathology</jtitle><addtitle>Avian Pathol</addtitle><date>2002-10-01</date><risdate>2002</risdate><volume>31</volume><issue>5</issue><spage>485</spage><epage>492</epage><pages>485-492</pages><issn>0307-9457</issn><eissn>1465-3338</eissn><abstract>Differences in the relative pathogenicity of variant (1084 E and GLS) and standard (Edgar and STC) infectious bursal disease virus (IBDV) strains were observed after propagation in the bursa of Fabricius, embryos, or cell cultures. Bursa-derived IBDV induced the most severe lesions in the bursa of Fabricius when compared with strains propagated in embryos or cell cultures. Embryo-derived IBDV induced moderate gross bursal lesions, whereas cell culture-derived IBDV did not damage the bursa grossly. A high frequency of virus re-isolations was obtained from bursal, spleen, and thymic samples collected from birds inoculated with bursa-derived or embryo-derived IBDV. Virus re-isolation occurred much less frequently from birds inoculated with cell culture-adapted IBDV. Serological evaluations demonstrated that bursa-derived IBDV strains induced a higher neutralizing antibody response than did embryo-derived or cell culture-derived strains. These results document that the relative pathogenicity and immunogenicity of IBDV is reduced following propagation in embryos or cell cultures.</abstract><cop>England</cop><pub>Taylor & Francis Group</pub><pmid>12427342</pmid><doi>10.1080/0307945021000005851</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Avian pathology, 2002-10, Vol.31 (5), p.485-492 |
| issn | 0307-9457 1465-3338 |
| language | eng |
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| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Science and Technology Collection (Reading list) |
| subjects | Animals Birnaviridae Infections - immunology Birnaviridae Infections - pathology Birnaviridae Infections - veterinary Bursa of Fabricius - immunology Bursa of Fabricius - pathology Cells, Cultured Chick Embryo - virology Chickens Infectious bursal disease virus - growth & development Infectious bursal disease virus - immunology Infectious bursal disease virus - pathogenicity Poultry Diseases - immunology Poultry Diseases - pathology Virulence Virus Replication |
| title | Characterization of the antigenic, immunogenic, and pathogenic variation of infectious bursal disease virus due to propagation in different host systems (bursa, embryo, and cell culture). III. Pathogenicity |
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