Janus nanoparticles: an efficient intelligent modern nanostructure for eradicating cancer

• Published in: Drug metabolism reviews 2021-10, Vol.53 (4), p.592-603
• Main Authors: Gheisari, Farshid, Shafiee, Mostafa, Abbasi, Milad, Jangjou, Ali, Izadpanah, Peyman, Vaez, Ahmad, Amani, Ali Mohammad
• Format: Article
• Language: English
• Subjects: biomedical; cancer; drug delivery; Janus nanoparticles; self-assembly
• ISSN: 0360-2532; 1097-9883
• DOI: 10.1080/03602532.2021.1878530

In the modern age, the struggle to generate appropriate bio-based materials and nano-scaled colloidal particulates for developed application domains, has already resulted in remarkable attempts in the advancement of regulated size and shape, anisotropy, and characteristics of nanostructures. The bottom-up development strategies of components are among the most important science areas throughout nanotechnology, in which the designed building blocks are often utilized to generate novel structures by random self-assembly. In biomedical applications, Janus nanoparticles (JNPs) are necessary. This is due to their effective stimulus-responsive properties, tunable structure, biocompatibility, containing two surfaces with various hydrophobic characteristics and distinct functional groups. Featuring two parts with differing hydrophobicity has been the most critical aspect of the Janus amphiphilic particles. Development of JNPs has been afforded, using imaging agents (e.g. gold (AU) for photoacoustic imaging processing (PAI), silver for surface-enhanced Raman scattering (SERS), and Fe 3 O 4 and MnO 2 to magnetic resonance imaging (MRI)). It is also to be mentioned that a number of other properties become salient - properties such as integration imaging factors into JNPs (like quantum dots, fluorescent dyes), multiple imaging methods for screening and diagnosis application can indeed be accomplished. Janus nanostructures have been promising platforms for bioengineering as therapeutic carriers, drug delivery vehicles, and biosensor equipment; they may also be employed for the transport of bioactive hydrophilic and hydrophobic materials. The main production approaches and major advancement of JNPs in the biomedical sector and cancer therapy will be described in this paper.