Joint modeling of multivariate hearing thresholds measured longitudinally at multiple frequencies

Pure-tone thresholds are used to estimate hearing acuity and, when measured longitudinally, can characterize age-related changes in hearing. Measured at multiple-frequencies, multiple-irregular time points, for right and left ears, these longitudinal studies of age-related hearing loss produce data...

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Bibliographic Details
Published in:Communications in statistics. Theory and methods 2018-01, Vol.47 (22), p.5418-5434
Main Authors: Gebregziabher, Mulugeta, Eckert, Mark A., Matthews, Lois J., Teklehaimanot, Abeba A., Dubno, Judy R.
Format: Article
Language:English
Subjects:
Acuity
Age
Clustering
Correlated data
Correlation analysis
Ear
Ears & hearing
Hearing loss
longitudinal hearing thresholds
mGLMM
Nesting
sGLMM multivariate outcomes
Statistical models
Thresholds
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Summary:Pure-tone thresholds are used to estimate hearing acuity and, when measured longitudinally, can characterize age-related changes in hearing. Measured at multiple-frequencies, multiple-irregular time points, for right and left ears, these longitudinal studies of age-related hearing loss produce data of inherent complexity due to: 1) multivariate outcomes at different frequencies; 2) longitudinal measurements taken at subject-specific time intervals; and 3) inter-ear correlations due to clustering and nesting. To address limitations in existing methods, we propose a multivariate generalized linear mixed model (mGLMM) and assess its performance. We demonstrate its application using a unique dataset from a cohort study of age-related hearing loss.
ISSN:0361-0926
1532-415X
DOI:10.1080/03610926.2017.1395045