The significant role of dietary intake of vitamin D in non-menopausal women health

Optimal vitamin D status is very important for reflecting not only bone but overall woman's health. The aim of the study was to determine pharmacokinetic variability of 25-hydroxy vitamin D, to reveal and quantify the most significant factors that affect its variability in the population of hea...

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Bibliographic Details
Published in:Women & health 2021-05, Vol.61 (5), p.420-430
Main Authors: Milovanovic, Jasmina R., Milovanovic, Olivera Z., Tomic Lucic, Aleksandra, Djokovic, Jelena, Cvetkovic, Tatjana, Zivanovic, Slavoljub, Barjaktarevic, Ana, Pantovic, Suzana, Radovanovic, Milan, Dimitrijevic, Aleksandra, Jankovic, Slobodan, Velickovic Radovanovic, Radmila
Format: Article
Language:English
Subjects:
25-hydroxy vitamin D
Calciferol
diet intake of vitamin D
Dietary intake
Dietary Supplements
Dosage
Eating
Female
Food intake
Health problems
healthy non-menopausal women
Humans
Life Style
Menopause
Nutritional Status
Pharmacokinetics
Pharmacology
Population
population pharmacokinetic analysis
Population studies
Software
Vitamin D
Vitamin D Deficiency - epidemiology
Vitamin D Deficiency - prevention & control
Women
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Summary:Optimal vitamin D status is very important for reflecting not only bone but overall woman's health. The aim of the study was to determine pharmacokinetic variability of 25-hydroxy vitamin D, to reveal and quantify the most significant factors that affect its variability in the population of healthy non-menopausal women using the population pharmacokinetic (PopPK) approach. The study population consisted of 74 healthy reproductive women aged from 35 to 50 years, without the use of any supplement. A population pharmacokinetics analysis was conducted using a nonlinear mixed-effects model software. A total of 35 factors were assessed: demographic, clinical, biochemical data and lifestyle factors. The average age and bodyweight of our participants were 40.11 ± 4.35 years 65.30 ± 6.80 kg, respectively. The observed mean serum concentration of 25-hydroxy vitamin D was 26.51 ± 13.49 ng/mL with a wide range of 6.97 to 59.89 ng/mL. Development final PopPK model of the clearance of 25-hydroxy vitamin D showed that only the average daily dose of vitamin D intake from food had a significant influence, with a magnitude of its effects of 0.00401. These results could help when individualizing vitamin D intake in the form of supplements, especially during the wintertime, in healthy reproductive women.
ISSN:0363-0242
1541-0331
DOI:10.1080/03630242.2021.1917480