Developing combination of artesunate with paclitaxel loaded into poly-d,l-lactic-co-glycolic acid nanoparticle for systemic delivery to exhibit synergic chemotherapeutic response

Objectives: Paclitaxel (PTX) has been indicated for the treatment of a variety of solid tumors, whereas artesunate (ART) has been reported to have the potential for use in combination chemotherapy. In this study, the combination of ART and PTX was prepared in nanoparticle to induce the synergic effe...

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Published in:Drug development and industrial pharmacy 2017-12, Vol.43 (12), p.1952-1962
Main Authors: Tran, Bao Ngoc, Nguyen, Hanh Thuy, Kim, Jong Oh, Yong, Chul Soon, Nguyen, Chien Ngoc
Format: Article
Language:English
Subjects:
anti-cancer
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Apoptosis - drug effects
Artemisinins - administration & dosage
Artemisinins - chemistry
Artemisinins - pharmacology
Artesunate
Breast Neoplasms - drug therapy
Cell Line, Tumor
combination therapy
Drug Carriers - chemistry
Humans
Lactic Acid - chemistry
nanoparticle
Nanoparticles - chemistry
paclitaxel
Paclitaxel - administration & dosage
Paclitaxel - chemistry
Paclitaxel - pharmacology
PLGA
Polyglycolic Acid - chemistry
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Summary:Objectives: Paclitaxel (PTX) has been indicated for the treatment of a variety of solid tumors, whereas artesunate (ART) has been reported to have the potential for use in combination chemotherapy. In this study, the combination of ART and PTX was prepared in nanoparticle to induce the synergic effect and improve therapeutic efficiency in treatment of breast cancer. Methods: Dual anticancer agents (PTX and ART) were loaded into Poly-D,L-lactic-co-glycolic acid (PLGA) nanoparticle (NP) by solvent evaporation technique from oil-in-water emulsion, stabilized with Tween 80. Physicochemical properties of obtained nanoparticles (PTX-ART-NPs) were characterized including particle size (Z), polydispersity index (PDI), zeta potentials (ZP), encapsulation efficiency (EE), and in-vitro drug release. Combination index (CI) was calculated to determine the synergic effect of the combination and select the best ratio of ART and PTX. The final NPs analyzed intracellular uptake, cytotoxicity assay, and apoptosis study. Results: The final NP had a small size (around 120 nm) with a narrow size distribution (PDI
ISSN:0363-9045
1520-5762
DOI:10.1080/03639045.2017.1357729