Improving the 6-Aminopenicillanic acid release process using vermiculite-alginate biocomposite bead on drug delivery system

• Published in: Drug development and industrial pharmacy 2021-09, Vol.47 (9), p.1489-1501
• Main Authors: Soleimanpour moghadam, Nona, Azadmehr, Amirreza, Hezarkhani, Ardeshir
• Format: Article
• Language: English
• Subjects: 6-Aminopenicillanic acid; antibacterial activity; drug release; equilibrium and kinetic studies; vermiculite-alginate biocomposite
• ISSN: 0363-9045; 1520-5762
• DOI: 10.1080/03639045.2021.2001492

The present study deals with developing vermiculite (VMT)-alginate (Alg) composites with different cross-linker concentrations (CaCl 2 ) to deliver the controlled 6-aminopenicillin acid (6-APA). The Characterization of synthesized composites was conducted by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analyses. Optimization attempts were explored via the response surface method (RSM) to best predict the actual amount of compound. The adsorption capacity of 6-APA onto this adsorbent was found to be 208.33 mg/g, which was higher than that for other clays. The equilibrium and Kinetic studies (chemical reaction and diffusion-based models) indicated that drug absorption on VMT-Alg is homogeneous with chemical interaction. An increase in cross-linker (CaCl 2 ) concentration leads to improvement in the drug encapsulation efficiency while having no significant effect on loading efficiency. The in-vitro release of the pure drug shows a rapid burst release followed by 100% cumulative release within 6 h. Whereas, the synthesized drug with Alg substantially showed less release of 43% after 8 h. Release experiments revealed that the presence of the CaCl 2 delayed the release of the 6-APA less than 35% after 12 h. The kinetic release of 6-APA is followed by the Korsmeyer-Peppas model based on Fick's law mechanism due to the kinetic exponent (n