Low Vitamin D Status at Admission as a Risk Factor for Poor Survival in Hospitalized Patients With COVID-19: An Italian Retrospective Study

Preliminary findings suggest a relationship between lower serum 25-hydroxyvitamin D [25(OH)D] levels and incidence and severity of COVID-19. The aim of this study was to evaluate the relationship between vitamin D status at admission and different markers of inflammation, coagulation, and sepsis in...

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Published in:Journal of the American College of Nutrition 2022-04, Vol.ahead-of-print (ahead-of-print), p.1-16
Main Authors: Infante, Marco, Buoso, Andrea, Pieri, Massimo, Lupisella, Santina, Nuccetelli, Marzia, Bernardini, Sergio, Fabbri, Andrea, Iannetta, Marco, Andreoni, Massimo, Colizzi, Vittorio, Morello, Maria
Format: Article
Language:English
Subjects:
COVID-19
cytokine storm
inflammatory markers
mortality
SARS-CoV-2
Vitamin D status
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Summary:Preliminary findings suggest a relationship between lower serum 25-hydroxyvitamin D [25(OH)D] levels and incidence and severity of COVID-19. The aim of this study was to evaluate the relationship between vitamin D status at admission and different markers of inflammation, coagulation, and sepsis in hospitalized patients with COVID-19. We conducted a retrospective study on 137 consecutive patients with SARS-CoV-2 infection and available data on serum 25(OH)D levels, who were admitted to our Institution between March 1 and April 30, 2020. Patients were divided into two groups: survivors (n = 78; 57%) and non-survivors (n = 59; 43%). At admission, all patients showed hypovitaminosis D. Median total serum 25(OH)D levels at admission were significantly higher in survivors than non-survivors (12 ng/mL vs 8 ng/mL; p 
ISSN:0731-5724
2769-7061
1541-1087
2769-707X
DOI:10.1080/07315724.2021.1877580