Chemical and Photochemical Ligation of Oligonucleotide Blocks

Several efficient means for joining oligonucleotides in dilute solution by non-natural internucleotide bridges are discussed. It is also shown that an oligonucleotide containing a -OP(O)(O − )S- link can hnction as an effective template in PCR amplification and that oligonucleotide probes containing...

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Bibliographic Details
Published in:Nucleosides & nucleotides 1997-05, Vol.16 (5-6), p.643-652
Main Authors: Letsinger, Robert L., Wu, Taifeng, Elghanian, Robert
Format: Article
Language:English
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Summary:Several efficient means for joining oligonucleotides in dilute solution by non-natural internucleotide bridges are discussed. It is also shown that an oligonucleotide containing a -OP(O)(O − )S- link can hnction as an effective template in PCR amplification and that oligonucleotide probes containing stilbenedicarboxamide groups can serve in monitoring the presence of mismatched bases in an oligonucleotide target.
ISSN:0732-8311
DOI:10.1080/07328319708002929