Chemical and Photochemical Ligation of Oligonucleotide Blocks

Several efficient means for joining oligonucleotides in dilute solution by non-natural internucleotide bridges are discussed. It is also shown that an oligonucleotide containing a -OP(O)(O − )S- link can hnction as an effective template in PCR amplification and that oligonucleotide probes containing...

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Published in:Nucleosides & nucleotides 1997-05, Vol.16 (5-6), p.643-652
Main Authors: Letsinger, Robert L., Wu, Taifeng, Elghanian, Robert
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Language:English
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description Several efficient means for joining oligonucleotides in dilute solution by non-natural internucleotide bridges are discussed. It is also shown that an oligonucleotide containing a -OP(O)(O − )S- link can hnction as an effective template in PCR amplification and that oligonucleotide probes containing stilbenedicarboxamide groups can serve in monitoring the presence of mismatched bases in an oligonucleotide target.
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title Chemical and Photochemical Ligation of Oligonucleotide Blocks
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