Synthesis of Fully Protected Nucleoside- Folic Acid Conjugated Phosphoramidites and Their Incorporation into Antisense Oligonuleotides

A novel synthesis of the nucleoside-folic acid conjugates has been accomplished. This approach allowed us to synthesize several analogs, which were converted to phosphoramidites and successfully incorporated into therapeutically active antisense oligonucleotides.

Saved in:
Bibliographic Details
Published in:Nucleosides & nucleotides 1999-06, Vol.18 (6-7), p.1471-1472
Main Authors: Bhat, Balkrishen, Balow, Guity, Guzaev, Andrei, Cook, P. Dan, Manoharan, Muthiah
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A novel synthesis of the nucleoside-folic acid conjugates has been accomplished. This approach allowed us to synthesize several analogs, which were converted to phosphoramidites and successfully incorporated into therapeutically active antisense oligonucleotides.
ISSN:0732-8311
2332-3892
DOI:10.1080/07328319908044756