Synthesis of Fully Protected Nucleoside- Folic Acid Conjugated Phosphoramidites and Their Incorporation into Antisense Oligonuleotides

A novel synthesis of the nucleoside-folic acid conjugates has been accomplished. This approach allowed us to synthesize several analogs, which were converted to phosphoramidites and successfully incorporated into therapeutically active antisense oligonucleotides.

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Published in:Nucleosides & nucleotides 1999-06, Vol.18 (6-7), p.1471-1472
Main Authors: Bhat, Balkrishen, Balow, Guity, Guzaev, Andrei, Cook, P. Dan, Manoharan, Muthiah
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Language:English
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container_end_page 1472
container_issue 6-7
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container_title Nucleosides & nucleotides
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creator Bhat, Balkrishen
Balow, Guity
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description A novel synthesis of the nucleoside-folic acid conjugates has been accomplished. This approach allowed us to synthesize several analogs, which were converted to phosphoramidites and successfully incorporated into therapeutically active antisense oligonucleotides.
doi_str_mv 10.1080/07328319908044756
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title Synthesis of Fully Protected Nucleoside- Folic Acid Conjugated Phosphoramidites and Their Incorporation into Antisense Oligonuleotides
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