Conserved Short Sequences in Promoter Regions of Human Genome

Recognition of promoter elements by the transcription factors is one of the early initial and crucial steps in gene expression and regulation. In prokaryotes, there are clear signals to identify the promoter regions like TATAAT at around −10 and TTGACA at −35 positions from transcription start site...

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Bibliographic Details
Published in:Journal of biomolecular structure & dynamics 2010-04, Vol.27 (5), p.599-610
Main Authors: Putta, Padmavathi, Mitra, Chanchal K.
Format: Article
Language:English
Subjects:
Base Sequence
Conserved Sequence
Databases, Nucleic Acid
Gene expression
Genome, Human - genetics
Genomes
Guanylate cyclase
Humans
Inverted Repeat Sequences - genetics
MicroRNAs - genetics
miRNA
Molecular Sequence Data
Nucleotides - genetics
Prokaryotes
Promoter Regions, Genetic
Promoters
Transcription factors
Transcription Initiation Site
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Summary:Recognition of promoter elements by the transcription factors is one of the early initial and crucial steps in gene expression and regulation. In prokaryotes, there are clear signals to identify the promoter regions like TATAAT at around −10 and TTGACA at −35 positions from transcription start site (TSS). In eukaryotes the promoter regions are structurally more complex and there are no conserved or consensus sequences similar to the ones found in prokaryotic promoters. We have located a set of GC rich short sequences (
ISSN:0739-1102
1538-0254
DOI:10.1080/07391102.2010.10508574