Preliminary assessment of the subjective effects of electronic-cigarettes in young-adult low-dose electronic-cigarette users: Effects of nicotine dose and e-liquid flavor

The present study evaluated the effects of nicotine concentration (0-10 mg/ml) and flavor (gummy bear vs unflavored) on the subjective experiences of vaporized nicotine in young adult low-dose nicotine (3 mg/ml) ECIG users. Eight young adult ECIG users were recruited. A single blinded crossover stud...

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Bibliographic Details
Published in:Journal of American college health 2023-07, Vol.71 (6), p.1887-1896
Main Authors: Peterson, Makenzie L., Clark, Carson T., Lynch, Cayla J., Cooper, James T., Gelfman, Noah, Blumenstein, Julia, Hansen, Rodney, Porter, Joseph H., Hillhouse, Todd M.
Format: Article
Language:English
Subjects:
Addictive Behavior
Aversive
Cigarettes
Drug Use
Electronic cigarettes
Electronic Equipment
Flavors
Health Behavior
Heart rate
Liquids
Nicotine
Physiology
Reinforcement
Smoking
Subjective experiences
Young Adults
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Summary:The present study evaluated the effects of nicotine concentration (0-10 mg/ml) and flavor (gummy bear vs unflavored) on the subjective experiences of vaporized nicotine in young adult low-dose nicotine (3 mg/ml) ECIG users. Eight young adult ECIG users were recruited. A single blinded crossover study was used. Participants were instructed to take ten 1.5 second puffs, each separated by 20 seconds. After self-administration, heart rate was recorded, and participants completed the Drug Effects, Direct Effects of Nicotine, and Direct Effects of ECIG questionnaires. ECIG user's standard daily nicotine dose influenced the rewarding and aversive effects of nicotine as the 10 mg/ml dose was found to be aversive in this user group. The combination of flavor and nicotine increased the subjective effects of ECIGs. Flavored e-liquids contribute to the reinforcing properties of nicotine by enhancing the subjective effects, which may lead to continued ECIG use.
ISSN:0744-8481
1940-3208
DOI:10.1080/07448481.2021.1950162