Protective effect of standardised fruit extract of Garcinia cowa Roxb. ex Choisy against ethanol induced gastric mucosal lesions in Wistar rats

The fruit of Garcinia is a rich and valuable source of bioactive compounds and is traditionally used for treating wounds and ulcers. The present study was carried out to investigate the protective effect of chromatographically standardized fruit extract of Garcinia cowa (GCE) on ethanol-induced gast...

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Bibliographic Details
Published in:Annals of medicine (Helsinki) 2021-01, Vol.53 (1), p.1697-1709
Main Authors: Gupta, Prakash Chandra, Kar, Ashish, Sharma, Nisha, Singh, Prashant Kumar, Goswami, Naba Kumar, Kumar, Satyanshu
Format: Article
Language:English
Subjects:
Animals
Anti-Ulcer Agents - pharmacology
Anti-Ulcer Agents - therapeutic use
antioxidant
Ethanol
Ethanol - chemistry
Fruit
Garcinia - chemistry
Garcinia cowa
gastric lesion
Humans
malondialdehyde
Malondialdehyde - blood
Pharmacology
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Rats
Rats, Wistar
Stomach Ulcer - chemically induced
Stomach Ulcer - metabolism
Stomach Ulcer - prevention & control
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Summary:The fruit of Garcinia is a rich and valuable source of bioactive compounds and is traditionally used for treating wounds and ulcers. The present study was carried out to investigate the protective effect of chromatographically standardized fruit extract of Garcinia cowa (GCE) on ethanol-induced gastric lesions in rats and its possible mechanisms. The effect of GCE (200 and 400 mg/kg body weight) was evaluated by determining various gastric ulcer parameters like gastric wall mucus, non-protein sulfhydryls (NP-SH) content, microvascular permeability, endogenous antioxidant enzyme, and gastric histopathological study. Oral administration of GCE at doses of 200 and 400 mg/kg exhibited significant (p 
ISSN:0785-3890
1365-2060
DOI:10.1080/07853890.2021.1981548