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Effect of vitamin D deficiency on spatial contrast sensitivity function
Vitamin D has regulatory effects on non-skeletal tissues including neurons. The contrast sensitivity function occurs as a result of interaction between retinal neurons. The association between plasma vitamin D deficiency and contrast sensitivity function was investigated. Forty-one eyes of 41 subjec...
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| Published in: | Clinical and experimental optometry 2022-10, Vol.105 (7), p.733-739 |
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| container_title | Clinical and experimental optometry |
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| creator | Arikan, Sedat Kamis, Fatih |
| description | Vitamin D has regulatory effects on non-skeletal tissues including neurons. The contrast sensitivity function occurs as a result of interaction between retinal neurons.
The association between plasma vitamin D deficiency and contrast sensitivity function was investigated.
Forty-one eyes of 41 subjects with vitamin D deficiency with plasma vitamin D level |
| doi_str_mv | 10.1080/08164622.2021.1969212 |
| format | article |
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The association between plasma vitamin D deficiency and contrast sensitivity function was investigated.
Forty-one eyes of 41 subjects with vitamin D deficiency with plasma vitamin D level <20 ng/mL (Group 1), and 30 eyes of 30 subjects without vitamin D deficiency with plasma vitamin D level ≥20 ng/mL (Group 2), were included in this prospective study. OPTEC 6500 was used to measure the contrast sensitivity function at all spatial frequencies involving 1.5 cpd, 3 cpd, 6 cpd, 12cpd, and 18 cpd. The average and sectorial retinal nerve fibre layer thickness, the average and minimum ganglion cell-inner plexiform thickness and tear meniscus height were measured by using optical coherence tomography.
A significant difference was present between Group 1 and Group 2 regarding the plasma vitamin D level (12.4 ± 4.7 ng/mL in Group 1 versus 27.1 ± 6.7 ng/mL in Group 2 p < 0.001). All spatial frequencies of contrast sensitivity function were significantly greater in Group 2 than those in Group 1, as follows: 45 ± 22.6 in Group 1 versus 57.5 ± 20.9 in Group 2, p = 0.08 in 1.5cpd; 71.3 ± 31.3 in Group 1 versus 91.8 ± 27.8 in Group 2, p = 0.001 in 3cpd; 77.9 ± 39.9 in Group 1 versus 100.4 ± 38.4 in Group 2, p = 0.013 in 6cpd; 32 ± 17.5 in Group 1 versus 48.8 ± 25.2 in Group 2, p = 0.002 in 12cpd; and 12.1 ± 5 in Group 1 versus 17.5 ± 9.5 in Group 2, p = 0.001 in 18cpd. However, there were no significant difference between two groups in terms of retinal fibre layer thicknesses, ganglion cell-inner plexiform layer thicknesses, and tear meniscus height.
Vitamin D deficiency can lead to a decrease in contrast sensitivity function that is an indicator of visual quality. This may be an underlying reason for certain visual complaints.</description><identifier>ISSN: 0816-4622</identifier><identifier>EISSN: 1444-0938</identifier><identifier>DOI: 10.1080/08164622.2021.1969212</identifier><identifier>PMID: 34459358</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Plasma ; Retina ; Retinal nerve fibre layer ; spatial contrast sensitivity function ; Vitamin D ; vitamin D deficiency ; Vitamin deficiency</subject><ispartof>Clinical and experimental optometry, 2022-10, Vol.105 (7), p.733-739</ispartof><rights>2021 Optometry Australia 2021</rights><rights>2021 Optometry Australia</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c324t-b042ef019b83c5505e9628fce929e2866cf241727e32a454816303137adefe613</citedby><cites>FETCH-LOGICAL-c324t-b042ef019b83c5505e9628fce929e2866cf241727e32a454816303137adefe613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34459358$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arikan, Sedat</creatorcontrib><creatorcontrib>Kamis, Fatih</creatorcontrib><title>Effect of vitamin D deficiency on spatial contrast sensitivity function</title><title>Clinical and experimental optometry</title><addtitle>Clin Exp Optom</addtitle><description>Vitamin D has regulatory effects on non-skeletal tissues including neurons. The contrast sensitivity function occurs as a result of interaction between retinal neurons.
The association between plasma vitamin D deficiency and contrast sensitivity function was investigated.
Forty-one eyes of 41 subjects with vitamin D deficiency with plasma vitamin D level <20 ng/mL (Group 1), and 30 eyes of 30 subjects without vitamin D deficiency with plasma vitamin D level ≥20 ng/mL (Group 2), were included in this prospective study. OPTEC 6500 was used to measure the contrast sensitivity function at all spatial frequencies involving 1.5 cpd, 3 cpd, 6 cpd, 12cpd, and 18 cpd. The average and sectorial retinal nerve fibre layer thickness, the average and minimum ganglion cell-inner plexiform thickness and tear meniscus height were measured by using optical coherence tomography.
A significant difference was present between Group 1 and Group 2 regarding the plasma vitamin D level (12.4 ± 4.7 ng/mL in Group 1 versus 27.1 ± 6.7 ng/mL in Group 2 p < 0.001). All spatial frequencies of contrast sensitivity function were significantly greater in Group 2 than those in Group 1, as follows: 45 ± 22.6 in Group 1 versus 57.5 ± 20.9 in Group 2, p = 0.08 in 1.5cpd; 71.3 ± 31.3 in Group 1 versus 91.8 ± 27.8 in Group 2, p = 0.001 in 3cpd; 77.9 ± 39.9 in Group 1 versus 100.4 ± 38.4 in Group 2, p = 0.013 in 6cpd; 32 ± 17.5 in Group 1 versus 48.8 ± 25.2 in Group 2, p = 0.002 in 12cpd; and 12.1 ± 5 in Group 1 versus 17.5 ± 9.5 in Group 2, p = 0.001 in 18cpd. However, there were no significant difference between two groups in terms of retinal fibre layer thicknesses, ganglion cell-inner plexiform layer thicknesses, and tear meniscus height.
Vitamin D deficiency can lead to a decrease in contrast sensitivity function that is an indicator of visual quality. This may be an underlying reason for certain visual complaints.</description><subject>Plasma</subject><subject>Retina</subject><subject>Retinal nerve fibre layer</subject><subject>spatial contrast sensitivity function</subject><subject>Vitamin D</subject><subject>vitamin D deficiency</subject><subject>Vitamin deficiency</subject><issn>0816-4622</issn><issn>1444-0938</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kD1vFDEQhi1ERI7AT0hkiYZmL_b4Y-0OlIQQKVIaqC2fz5Yc7dqH7QXdv49Pd6GgoJrmmXfeeRC6pGRNiSLXRFHJJcAaCNA11VIDhTdoRTnnA9FMvUWrAzMcoHP0vtZnQoAzzd-hc8a50EyoFbq_C8G7hnPAv2Ozc0z4Fm99iC765PY4J1x3tkU7YZdTK7Y2XH2qscXO73FYkmsxpw_oLNip-o-neYF-frv7cfN9eHy6f7j5-jg4BrwNG8LBB0L1RjEnBBFeS1DBeQ3ag5LSBeB0hNEzsFzw_gAjjLLR9k5eUnaBPh9zdyX_WnxtZo7V-WmyyeelGhBSglBkhI5--gd9zktJvZ2BkagexjXvlDhSruRaiw9mV-Jsy95QYg6mzatpczBtTqb73tUpfdnMfvt361VtB74cgZhCLrP9k8u0Nc3up1xCscnFatj_b7wA-NeLFA</recordid><startdate>20221003</startdate><enddate>20221003</enddate><creator>Arikan, Sedat</creator><creator>Kamis, Fatih</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20221003</creationdate><title>Effect of vitamin D deficiency on spatial contrast sensitivity function</title><author>Arikan, Sedat ; Kamis, Fatih</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c324t-b042ef019b83c5505e9628fce929e2866cf241727e32a454816303137adefe613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Plasma</topic><topic>Retina</topic><topic>Retinal nerve fibre layer</topic><topic>spatial contrast sensitivity function</topic><topic>Vitamin D</topic><topic>vitamin D deficiency</topic><topic>Vitamin deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arikan, Sedat</creatorcontrib><creatorcontrib>Kamis, Fatih</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental optometry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arikan, Sedat</au><au>Kamis, Fatih</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of vitamin D deficiency on spatial contrast sensitivity function</atitle><jtitle>Clinical and experimental optometry</jtitle><addtitle>Clin Exp Optom</addtitle><date>2022-10-03</date><risdate>2022</risdate><volume>105</volume><issue>7</issue><spage>733</spage><epage>739</epage><pages>733-739</pages><issn>0816-4622</issn><eissn>1444-0938</eissn><abstract>Vitamin D has regulatory effects on non-skeletal tissues including neurons. The contrast sensitivity function occurs as a result of interaction between retinal neurons.
The association between plasma vitamin D deficiency and contrast sensitivity function was investigated.
Forty-one eyes of 41 subjects with vitamin D deficiency with plasma vitamin D level <20 ng/mL (Group 1), and 30 eyes of 30 subjects without vitamin D deficiency with plasma vitamin D level ≥20 ng/mL (Group 2), were included in this prospective study. OPTEC 6500 was used to measure the contrast sensitivity function at all spatial frequencies involving 1.5 cpd, 3 cpd, 6 cpd, 12cpd, and 18 cpd. The average and sectorial retinal nerve fibre layer thickness, the average and minimum ganglion cell-inner plexiform thickness and tear meniscus height were measured by using optical coherence tomography.
A significant difference was present between Group 1 and Group 2 regarding the plasma vitamin D level (12.4 ± 4.7 ng/mL in Group 1 versus 27.1 ± 6.7 ng/mL in Group 2 p < 0.001). All spatial frequencies of contrast sensitivity function were significantly greater in Group 2 than those in Group 1, as follows: 45 ± 22.6 in Group 1 versus 57.5 ± 20.9 in Group 2, p = 0.08 in 1.5cpd; 71.3 ± 31.3 in Group 1 versus 91.8 ± 27.8 in Group 2, p = 0.001 in 3cpd; 77.9 ± 39.9 in Group 1 versus 100.4 ± 38.4 in Group 2, p = 0.013 in 6cpd; 32 ± 17.5 in Group 1 versus 48.8 ± 25.2 in Group 2, p = 0.002 in 12cpd; and 12.1 ± 5 in Group 1 versus 17.5 ± 9.5 in Group 2, p = 0.001 in 18cpd. However, there were no significant difference between two groups in terms of retinal fibre layer thicknesses, ganglion cell-inner plexiform layer thicknesses, and tear meniscus height.
Vitamin D deficiency can lead to a decrease in contrast sensitivity function that is an indicator of visual quality. This may be an underlying reason for certain visual complaints.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>34459358</pmid><doi>10.1080/08164622.2021.1969212</doi><tpages>7</tpages></addata></record> |
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| ispartof | Clinical and experimental optometry, 2022-10, Vol.105 (7), p.733-739 |
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| language | eng |
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| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Plasma Retina Retinal nerve fibre layer spatial contrast sensitivity function Vitamin D vitamin D deficiency Vitamin deficiency |
| title | Effect of vitamin D deficiency on spatial contrast sensitivity function |
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